Skip to main content
SpringerLink
Log in

Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 12.1 times higher in patients with a tumor diameter of 5.0–7.9 cm than in those with a tumor diameter of 2.0–5.0 cm. Among the other variables, the serum AFP level and sex were suggested to have effects similar to those of the tumor size on Tc-99m PMT uptake by HCC. The grade of morphological differentiation of the tumor was therefore most markedly related to Tc-99m PMT uptake.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Liaw YF, Tai DI, Chu CM, Lin DY, Sheen IS, Chen TJ, et al. Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis: a prospective study.Gastroenterology 90: 263–267, 1986.

    PubMed  CAS  Google Scholar 

  2. Yamada R, Sato M, Kawabata M, et al. Hepatic artery embolization in 120 patients with unresectable hepatoma.Radiology 148: 397–401, 1983.

    PubMed  CAS  Google Scholar 

  3. Kasugai H, Kojima J, Tatsuta M, Okuda S, Sasaki Y, Imaoka S, et al. Treatment of hepatocellular carcinoma by transcatheter arterial embolization combined with intraarterial infusion of a mixture of cisplatin and ethodized oil.Gastroenterology 97: 965–971, 1989.

    PubMed  CAS  Google Scholar 

  4. The liver cancer study group of Japan. Primary liver cancer in Japan.Cancer 60: 1400–1411, 1987.

    Article  Google Scholar 

  5. Boijsen E, Abrams HL. Roentgenologic diagnosis of primary cancer of the liver.Acta radiologica (diag.) 3: 257–277, 1965.

    CAS  Google Scholar 

  6. Reuter SR, Redman HC, Siders DB. The spectrum angiographic findings in hepatoma.Radiology 94: 89–94, 1970.

    PubMed  CAS  Google Scholar 

  7. Tanaka S, Kitamura T, Kasugai H, Okano Y, Tatsuta M, Okuda S. Early diagnosis of hepatocellular carcinoma: usefulness of ultrasonically guided fine-needle aspiration biopsy.J Clin Ultrasound 14: 11–16, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Hasegawa Y, Nakano S, Ibuka K, Hashizume T, Noguchi A, Sasaki Y, et al. Specific diagnosis of hepatocellular carcinoma by delayed hepatobiliary imaging.Cancer 57: 230–236, 1986.

    Article  PubMed  CAS  Google Scholar 

  9. Lee VW, O’Brien MJ, Devereux DF, Morris PM, Shapiro JH. Hepatocellular carcinoma: Uptake of Tc-99m IDA in primary tumor and metastasis.AJR 143: 57–61, 1984.

    PubMed  CAS  Google Scholar 

  10. Hasegawa Y, Nakano S, Hashizume T, Noguchi A, Ibuka K, Kasugai H, et al. Comparison of delayed imaging with Tc-99m PMT and Tc-99m DEID A for visualization of hepatoma.Clin Nucl Med 14: 526–531, 1989.

    Article  PubMed  CAS  Google Scholar 

  11. Breslow NE, Day NE, Davis W. Unconditional logistic regression for large strata.In Statistical methods in cancer research. Vol. 1. The analysis of case-control studies. IARC Scientific publications, No. 32, pp. 19–246, 1980.

  12. Edmondson HA, Steiner PE. Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies.Cancer 7: 462–503, 1954.

    Article  PubMed  CAS  Google Scholar 

  13. SAS Institute Inc. The logistic procedure.In SAS technical report. Cary, North Carolina: SAS Institute Inc., p-200, pp. 175–230, 1990.

    Google Scholar 

  14. Calvet X, Pons F, Bruix J, et al. Technetium-99m-DISIDA hepatobiliary agent in diagnosis hepatocellular carcinoma: relationship between detectability and tumor differentiation.J Nucl Med 29: 1916–1920, 1988.

    PubMed  CAS  Google Scholar 

  15. Nakashima T. Vascular changes and hemodynamics in hepatocellular carcinoma.In Hepatocellular Carcinoma. Okuda K, and Peters RL (ed.). New York: John Wiley and Sons, pp. 169–203, 1976.

    Google Scholar 

  16. Becker EF, Klein KM, Wolmann SR, et al. Characterization of hepatocellular carcinomas and initial transplantation generations.Cancer Research 33: 3330–3338, 1973.

    PubMed  CAS  Google Scholar 

  17. Sell S, Morris HP. Relationship of rat alpha-1-fetoprotein to growth rate and chromosome composition of Morris hepatoma.Cancer Research 34: 1413–1417, 1984.

    Google Scholar 

  18. Yasunaga H, Hirota T, Tsuchigame T, et al. Clinical significance of Tc-99m HIDA scintigraphy for hepatomas and detection of their distant metastasis. 19: 523–528, 1982.

    CAS  Google Scholar 

  19. Lee VW, Shapiro JH. Specific diagnosis of hepatoma using Tc-99m HIDA and other radionuclides.Eur J Nucl Med 8: 191–195, 1983.

    Article  PubMed  CAS  Google Scholar 

  20. Muramatsu Y, Nawano S, Takayasu S, Moriyama N, Yamada T, Yamasaki S, et al. Early hepatocellular carcinoma: MR imaging.Radiology 181: 209–213, 1991.

    PubMed  CAS  Google Scholar 

  21. Enomoto K, Fukunaga T, Okazumi S, Asano T, Kikuchi T, Yamamoto H, et al. Can fluorodeoxyglucose positron emission tomography evaluate the functional differentiation of hepatocellular carcinoma.KAKU IGAKU (Jpn J Nucl Med) 28: 1353–1356, 1991.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, The Center for Adult Diseases, Osaka, 3-3, Nakamichi-1-chome Higashinari-ku, 537, Osaka, Japan

    Yoshihisa Hasegawa & Shunichi Nakano

  2. Department of Field Research, The Center for Adult Diseases, Osaka

    Tomotaka Sobue

  3. Department of Radiology, The Center for Adult Diseases, Osaka

    Makoto Fujita

  4. Department of Pathology, The Center for Adult Diseases, Osaka

    Shingo Ishiguro

  5. Department of Surgery, The Center for Adult Diseases, Osaka

    Yo Sasaki & Shingi Imaoka

  6. Department of Innternal Medicine, The Center for Adult Diseases, Osaka

    Sachiko Tanaka, Hiroshi Kasugai, Atsuo Inoue & Jyunnosuke Kojima

Authors
  1. Yoshihisa Hasegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shunichi Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomotaka Sobue
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Makoto Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shingo Ishiguro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yo Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shingi Imaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sachiko Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroshi Kasugai
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Atsuo Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jyunnosuke Kojima
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hasegawa, Y., Nakano, S., Sobue, T. et al. Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma. Ann Nucl Med 8, 139–145 (1994). https://doi.org/10.1007/BF03165019

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03165019

Key words

Search

Navigation