Abstract
Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in both systolic function (left ventricular ejection fraction; LVEF) and diastolic function (peak filling rate; PFR) were also seen in these patients. A high incidence of myocardial involvement of these kinds of progressive muscular dystrophy was suggested.
This is a preview of subscription content, log in via an institution to check access.
References
Frankel KA, Rosser RJ. The pathology of the heart in progressive muscular dystrophy: Epimyocardial fibrosis.Hum Pathol 7: 375–386, 1976.
Bourne GH, Golarz MN. Muscular dystrophy in man and animals. New York, Hafner, pp. 323–362, 1963.
Kakulas BA, Adams RD. Diseases of muscle, Pathological foundations of clinical myology. Philadelphia, Harper & Row, pp. 331–459, 1985.
Takagi A, Sugita H. Handbook of internal medicine 56A. Tokyo, Nakayama, pp. 70–98, 1980.
Weisenfeld S, Messinger WJ. Cardiac involvement in progressive muscular dystrophy.Am Heart J 43: 170–187, 1952.
Perloff JK, Henze E, Schelbert HR. Alterations in regional myocardial metabolism, perfusion, and wall motion in Duchenne muscular dystrophy studied by radionuclide imaging.Circulation 69: 33–42, 1984.
Yamamoto S, Sotobata I, Indo T, Matsuoka Y, Kawai N, Matsushima H, et al. Evaluation of Myocardial involvement in muscular dystrophy with thallium-201 emission computed tomography.Jpn J Nucl Med 23: 773–782, 1986.
Yamamoto S, Matsushima H, Suzuki A, Sotobata I, Indo T, Matsuoka I, et al. A comparative study of thallium-201 single photon emission computed tomography and electrocardiography in Duchenne and other types of muscular dystrophy.Am J Cardiol 61: 836–843, 1988.
Jinnouchi S, Asai J, Inoue K, Hoshi H, Watanabe K. Evaluation of cardiomyopathy in Duchenne muscular dystrophy by Tl-201 myocardial SPECT.Jpn J Nucl Med 22: 1353–1359, 1985.
Nagamachi S, Jinnouchi S, Ono S, Hoshi H, Inoue K, Watanabe K. Tl-201 myocardial SPECT in patients with Duchenne’s muscular dystrophy: a long-term follow-up.Clin Nucl Med 14: 827–830, 1989.
Nagamachi S, Jinnouchi S, Inoue K, Inoue S, Hoshi H, Ono S, et al. Equilibrium radionuclide ventriculography in Duchenne’s cardiomyopathy.Clin Nucl Med 15: 887–892, 1990.
Nagamachi S, Jinnouchi S, Hoshi H, Inoue K, Yoshimura H, Ono S, et al. Serial changes of the myocardium in patients with Duchenne’s muscular dystrophy followed by cardiac nuclear imaging—5 year’s observation.Nippon ACTA Radiologica 50, 1415–1435, 1990.
Hoffman EP, Kunkel LM. Dystrophin abnormalities in Duchenne/Becker muscular dystrophy.Neuron 2: 1019–1029, 1989.
Hoffman EP, Kunkel LM, Angelini C, Clarke A, Johnson M, Harris B. Improved diagnosis of Becker muscular dystrophy by dystrophin testing.Neurology 39: 1011–1017, 1989.
Fukuyama Y, Osawa M, Suzuki H. Congenital progressive muscular dystrophy of the Fukuyama type-Clinical, Genetic and pathologic considerations.Brain & Development 3: 1–29, 1981.
Gerson MC. Cardiac nuclear medicine. New York, Mcgrawhill Book, pp. 173–192, 1987.
Merrick MV. Essentials of nuclear medicine. Edinburgh, Churchill Livingstone, pp. 72–107, 1984.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nagamachi, S., Inoue, K., Jinnouchi, S. et al. Cardiac involvement of progressive muscular dystrophy (Becker type, Limb-girdle type and Fukuyama type) evaluated by radionuclide method. Ann Nucl Med 8, 71–74 (1994). https://doi.org/10.1007/BF03164989
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164989