Abstract
The purpose of this study was to investigate Tl-201 as a tumor scanning agent in patients with malignant soft tissue sarcomas and to establish the sensitivity of this type of scintigraphy concerning local recurrences or metastases that may remain clinically suspected. Seventy-eight patients with malignant soft tissue sarcomas and 22 with benign soft tissue tumors were studied. Of these 78 malignant soft tissue sarcomas patients, the sensitivity of Tl-201(81.2%) was higher than that of Ga-67 (68.8%). Thirty-three out of 78 patients received a total of 95 consecutive scintigraphic follow-up examinations. Therapeutic effects was assessed by comparing the results of Tl-201 examinations with the clinical findings. Of these 33 patients, the therapeutic effects observed were as follows: complete remission 1, partial remission 8, progress of disease 1, and no remarkable change 23. Tl-201 scintigraphy has proved itself very useful not only in clinically detecting the malignant soft tissue sarcomas and in assessing therapeutic effects on these diseases, but also in assessing the follow-up patients with malignant soft tissue sarcomas.
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Touya JJ, Rahimian J, Grubbs DE, Corbus HF, Bennet LR. A noninvasive procedure forin vivo assay of a lung amine endothelial receptor.J Nucl Med 26: 1302–1307, 1985.
Suga K, Ariyoshi I, Nakanishi T, Utsumi H, Yamada N. Altered kinetics of123I-IMP in irradiated rabbit lungs.Nucl Med Commun 13: 282–289, 1992.
Suga K, Ariyoshi I, Nakanishi I, Utsumi H, Yamada N. Clinical and experimental studies on the mechanism of abnormal accumulation in lung scanning with123I-IMP.Nucl Med Commun 13: 33–40, 1992.
Suga K, Matsumoto T, Nakanishi T, Yokoyama T, Tanaka K, Nakamura H, et al. Clinical study on the mechanism of abnormal accumulation in lung scanning with N-isopropyl-p-I-123-iodoamphetamine (123I-IMP).Jpn J Nucl Med 25: 625–631, 1988.
Suematsu T, Narabayashi I, Takada Y, Ohbayashi K, Hirata Y, Oshitani T, et al. Delayed lung scintigraphy with N-isopropyl-I-123-p-iodoamphetamine in lung cancer and inflammatory disease.Jpn J Nucl Med 26: 45–53, 1989.
Nakajyo M, Nakabeppu Y, Iwashita S, Tanoue T, Taguchi M, Shinohara S. Differentiation of infiltrates between lung cancer and noncancerous lung disease by123I-IMP lung imaging.Nippon Acta Radiol 50: 164–171, 1990.
Nakajyo M, Uchiyama N, Shimada J, Shinohara S, Iriki A, Hirotsu Y, et al. Differentiation of bronchogenic carcinoma from secondary changes, obstructive pneumonia and/or collapse by123I-IMP lung imaging.Ann Nucl Med 4: 1–13, 1990.
Nakajyo N, Shimada J, Shimozono M, Uchiyama N, Hiraki Y, Shinohara S. Serial lung imaging with123I-IMP in localized pulmonary lesions.Jpn J Nucl Med 25: 441–450, 1988.
Kosuda S, Kawahara S, Tamura K, Ishikawa N, Ono A, Kubo A, et al. N-isopropyl-p-[I-123]Iodoamphetamine lung imaging in a patient with chronic pulmonary thromboembolism.Clin Nucl Med 14: 756–758, 1989.
Mena I, Thompson C, Mason G. Lung first-pass extraction of N-isopropyl-p-I-123-iodoamphetamine in patients with chronic obstructive pulmonary disease.Clin Nucl Med 9: 5–38, 1984.
Ikeda H, Mariko M, Komatsu M, Takahashi K, Yasui S, Takahashi K. Prolonged123I-IMP retention in pulmonary disease.Eur J Nucl Med 15: 646–648, 1989.
Kato K, Harada S, Takahashi T, Katsuragawa S, Yanagisawa T. Effects of cigarette smoking on iodine 123 N-isopropyl-p-iodoamphetamine clearance from the lung.Eur J Nucl Med 18: 801–805, 1991.
Balikian JP, Herman PG. Non-Hodgkin’s lymphoma of the lungs.Radiology 132: 569–576, 1979.
Bosanko CMM, Korobkin M, Fantone JC, Rubin SB, Lynch JP. Lobar primary pulmonary lymphoma: CT findings.J Comput Assist Tomogr 15: 679–682, 1991.
Rahimian J, Glass EC, Touya JJ, Akber SF, Graham LS, Bennet LR. Measurement of metabolic extraction of tracers in the lung using a multiple indicator dilution technique.J Nucl Med 25: 31–37, 1984.
L’Hoste RJ, Filippa DA, Lieberman PH, Bretsky S. Primary pulmonary lymphomas. A clinicopathologic analysis of 36 cases.Cancer 54: 1387–1406, 1984.
Freeman CB, Berg JW, Cuttler SJ. Occurence and prognosis of extranodal lymphoma.Cancer 29: 252–260, 1972.
Hansmann GML, Zwingers T, Lennert K. Primary lymphomas of the lung: morphological, immunohistochemical and clinical features.Histopathology 16: 519–531, 1990.
Turner RR, Colby TV, Dogget RS. Well-differentiated lymphocytic lymphoma—A study of 47 patients with primary manifestation in the lung.Cancer 54: 2088–2094, 1984.
Lewis ER, Caskey CI, Fishman EK. Lymphoma of the lung: CT findings in31 patients.AJR 156: 711–714, 1991.
Koss M, Hochholzer L, Nichols PW, Wehunt W, Lazarus A. A primary non-Hodgkin’s lymphoma and pseudolymphoma of the lung. A study of 161 patients.Hum Pathol 14: 1024–1038, 1983.
Weiss LM, Yousem SA, Warnke RA. Non-Hodgkin’s lymphomas of the lung—A study of 19 cases emphasizing the utility of frozen section immunologic studies in differential diagnosis.Am J Surg Patholo 9: 490–496, 1985.
Kennedy JL, Hathwani N, Burke J, Hill LR, Rappaport H. Pulmonary lymphomas and other pulmonary lymphoid lesions—A clinicopathological and immunologic study of 64 patients.Cancer 56: 539–552, 1985.
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Terui, S., Terauchi, T., Abe, H. et al. On clinical usefulness of Tl-201 scintigraphy for the management of malignant soft tissue tumors. Ann Nucl Med 8, 55–64 (1994). https://doi.org/10.1007/BF03164987
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DOI: https://doi.org/10.1007/BF03164987