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The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia

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Abstract

The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of the lag period observed during the emptying of solid foods from the stomach. Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with99mTc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p < 0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Baskent University, Turkey

    Ayse Aktas

  2. Department of Nuclear Medicine, Hacettepe University, Turkey

    Biray Caner

  3. Department of Biostatistics, Hacettepe University, Turkey

    Turhan Mentes

  4. Department of Gastroenterology, Gulhane Militay Medical School, Turkey

    Feyzullah Ozturk

  5. Department of Nuclear Medicine, Gulhane Militay Medical School, Turkey

    Hikmet Bayhan & Yavuz Narin

Authors
  1. Ayse Aktas
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  2. Biray Caner
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  3. Feyzullah Ozturk
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  4. Hikmet Bayhan
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  5. Yavuz Narin
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  6. Turhan Mentes
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Additional information

This study was performed at Gulhane Military Medical School and Hacettepe University, Faculty of Medicine.

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Aktas, A., Caner, B., Ozturk, F. et al. The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia. Ann Nucl Med 13, 231–234 (1999). https://doi.org/10.1007/BF03164897

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  • DOI: https://doi.org/10.1007/BF03164897

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