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Influence of age and gender on iodine-123 MIBG kinetics in normal lung

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Abstract

Iodine-123 MIBG is a biochemical marker that can be used to monitor pulmonary norepinephrine (NE) metabolism. The purpose of this study was to characterize pulmonary I-123 MIBG kinetics in relation to age and gender.

Materials and Methods

Seventeen healthy volunteers and 14 patients with no cardiac or pulmonary disorders were included in this study (age range: 24 to 88 years, mean age 50.2 ± 17.6 years; 16 males, 15 females). Planar images were obtained 15 min (early) and 3 h (delayed) after injection of I-123 MIBG (111 MBq). Pulmonary uptake of I-123 MIBG was quantified based on the lung-to-mediastinum ratio (LMR) on early and delayed images. The lung clearance rate (LCR) was calculated from both the early and delayed images.

Results

Both early and delayed LMR values increased slightly, although they showed no significant correlations with age. There was a significant inverse correlation between LCR and age (r = −0.57, p < 0.001). Neither LCR nor LMR differed significantly between male and female patients, but the mean age of the men was lower than that of the women.

Conclusions

Pulmonary I-123 MIBG kinetics may reflect age-dependent changes in NE metabolism. The effects of age should be taken into account when assessing pulmonary NE metabolism with I-123 MIBG.

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Authors and Affiliations

  1. Department of Radiology, National Minami Okayama Hospital, 4066 Hayashima-cho, Tsukubo-gun, 701-0304, Okayama, Japan

    Noriko Kanzaki

  2. Department of Internal Medicine, National Minami Okayama Hospital, Japan

    Ryo Soda, Kiyoshi Takahashi & Masayoshi Kibata

  3. Department of Clinical Research Institute and Department of Neurology, National Minami Okayama Hospital, Japan

    Keiko Sato & Toshiyuki Hayabara

  4. Department of Radiology, Okayama University School of Medicine, Japan

    Yoshihiro Takeda & Yoshio Hiraki

Authors
  1. Noriko Kanzaki
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  2. Ryo Soda
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  3. Kiyoshi Takahashi
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  4. Keiko Sato
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  5. Toshiyuki Hayabara
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  6. Masayoshi Kibata
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  7. Yoshihiro Takeda
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  8. Yoshio Hiraki
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Kanzaki, N., Soda, R., Takahashi, K. et al. Influence of age and gender on iodine-123 MIBG kinetics in normal lung. Ann Nucl Med 12, 225–229 (1998). https://doi.org/10.1007/BF03164851

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  • DOI: https://doi.org/10.1007/BF03164851

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