Abstract
In a patient with ocular melanoma scintigraphy obtained with99mTc-GSH clearly demonstrated the histologically proven ocular lesion both in planar and SPECT images.99mTc-sestamibi study obtained in the same patient three days later was negative.99mTc-GSH is a potential alternative to the currently used radiopharmaceuticals for imaging both cutaneous and ocular melanomas and their metastases.
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Thomas CI, Krohmer JS, Storaasli JP. Detection of intraocular tumors with radioactive phosphorus.Arch Ophtalmol 47: 276–286, 1952.
Beierwaltes WH, Varma VM, Liebermann LM, et al. Scintillation scanning of malignant melanomas with radioiodinated quinoline derivatives.J Lab Clin Med 72: 485–494, 1968.
Dencker L, Larsson B, Olander K, Ullberg S. A new melanoma seeker for possible clinical use: Selective accumulation of radiolabelled thiouracil.Br J Cancer 45: 95–104, 1982.
Holman BL, Wick MM, Kaplan ML, et al. The relationship of the eye uptake of N-isopropyl-p-[I-123]iodoamphetamine to melanin production.J Nucl Med 25: 315–319, 1984.
Ono S, Fukunaga M, Otsuka N, et al. Visualization of ocular melanoma with N-isopropyl-p-[I-123]-iodoamphetamine.J Nucl Med 29: 1448–1450, 1988.
Van Langevelde A, Bakker CNM, Boer H, et al. Potential radiopharmaceuticals for the detection of ocular melanoma. Part II. Iodoquinoline derivatives and67Ga-citrate.Eur J Nucl Med 12: 96–104, 1986.
Bomanji J, Garner A, Prasad J, et al. Characterization of ocular melanoma with cutaneous melanoma antibodies.Br J Ophthal 71: 647–650, 1987.
Bomanji J, Hungerford JL, Granowska M, et al. Radioimmunoscintigraphy of ocular melanoma with99mTc labelled cutaneous melanoma antibody fragments.Br J Ophthal 71: 651–658, 1987.
Scheidauer K, Markl A, Leinsinger MG, et al. Immunoscintigraphy in intraocular malignant melanoma.Nucl Med Commun 9: 669–679, 1988.
Liewendahl K, Pyrhönen S. Radioimmunodetection and radioimmunotherapy of malignant melanoma.Acta Oncologica 32: 717–721, 1993.
Ercan MT, Aras T, Aktaş A, et al. Accumulation of99mTcglutathione in head and neck tumors.Nucl-Med 33: 224–228, 1994.
Duman Y, Burak Z, Ercan MT, et al. Clinical evaluation of metastases of malignant melanoma imaging with Tc-99m-glutathione and Tc-99m-anti-melanoma antibody: A comparative study.Nucl Med Commun 16: 927–935, 1995.
Abdel-Dayem HM, Scott AM, Macapinlac HA, et al. Role of Tl-201 chloride and Tc-99m sestamibi in tumor imaging.In Freeman LM (ed.): Nuclear Medicine Annual 1994, New York, Raven Press Ltd., pp. 181–234, 1994.
Ercan MT, Bekdik CF, Sarizi T. Tc-99m-glutathione: labelling and distribution in rats.Int J Appl Rad Isotopes 29: 697–698, 1978.
Chakraborty AK, Ueda M, Mishima Y, Ichihashi M. Intracellular glutathione and its metabolizing enzyme activities in a metastatic variant melanoma cell line.Melanoma Res 2: 315–319, 1992.
Reed DJ. Regulation of reductive processes by glutathione.Biochem Pharmacol 35: 7–13, 1986.
Reed DJ. Glutathione: toxicological implications.Ann Rev Pharmacol Toxicol 30: 603–631, 1990.
Reed DJ, Fariss MW. Glutathione depletion and susceptibility.Pharmacol Rev 36: 25–33, 1984.
Novi AM. Regression of aflatoxin B1-increased hepatocellular carcinomas by reduced glutathione.Science 212: 541–542, 1981.
Coates A, Tripp E. Glutathione content of human malignant melanoma cell lines: correlation of flow cytometric and biochemical assays and application to human tumor aspirates.Melanoma Res 1: 327–332, 1992.
Mannervik B, Castro VM, Danielson VH, et al. Expression of class Pi glutathione transferase in human malignant melanoma cells.Carcinogenesis 8: 1929–1932, 1987.
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Tutuş, A., Erkiliç, K., Ercan, M.T. et al. Scintigraphic visualization of ocular melanoma with Tc-99m glutathione. Ann Nucl Med 11, 143–146 (1997). https://doi.org/10.1007/BF03164823
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DOI: https://doi.org/10.1007/BF03164823