Abstract
A 72-year-old woman with hypertension showed no sign of myocardial accumulation of123I-BMIPP, and201Tl and123I-MIBG scintigraphy demonstrated normal findings. Electrocardiography showed left axis deviation with inverted T waves in leads I, aVL, V2–6 and QT prolongation. Coronary arteriography, two dimensional echo cardiography and laboratory data showed no abnormality. Her 66-year-old sister with non-insulin-dependent diabetes mellitus also had no myocardial BMIPP uptake, but had normal201Tl finding. ECG and chest film findings were normal. Laboratory data indicated slightly high fasted blood glucose, triglyceride and total cholesterol. Four sons of a 72-year-old woman also underwent BMIPP scintigraphy. No BMIPP uptake was also observed in her 2nd son (49 years old) and his electrocardiogram showed QT prolongation. Since these rare findings indicating no myocardial BMIPP uptake were seen in a family, we suspected that a hereditary myocardial metabolic abnormality accounted for them.
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Knapp FF Jr, Amburose KR, Goodman MM. New radioiodinated methyl-branched fatty acids for cardiac studies.Eur J Nucl Med 12: S39–44, 1986.
Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, Konishi J, et al. Regional metabolic abnormality in relation to perfusion and wall motion in patients with myocardial infarction: assessment with emission tomography using an iodinated branched fatty acid.J Nucl Med 33: 659–667, 1992.
Saito T, Yasuda T, Gold HK, Leinbach R, Livini E, Elmaleh D, et al. Differentiation of regional perfusion and fatty acid uptake in zones of myocardial injury.Nucl Med Commun 12: 663–675, 1991.
Kurata C, Taniguchi T, Aoshima S, Kobayashi A, Yamazaki N, Kawa H, et al. Myocardial emission computed tomography with iodine-123-labeled beta methyl branched fatty acid in patients with hypertrophic cardiomyopathy.J Nucl Med 33: 6–13, 1992.
Taki J, Nakajima K, Bunko H, Shimizu M, Taniguchi M, Hisada K. Iodine-123-labeled BMIPP fatty acid myocardial scintigraphy in patients with hypertrophic cardiomyopathy: SPECT comparison with stress201Tl.Nucl Med Commun 14: 181–188, 1993.
Takeishi Y, Chiba J, Abe S, Tonooka I, Komatani A, Tomoike H. Heterogeneous myocardial distribution of iodine-123 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in patients with hypertrophie cardiomyopathy.Eur J Nucl Med 19: 775–782, 1992.
Geeter FD, Franken PR, Knapp FF Jr, Bossuyt A. Relationship between blood flow and fatty acid metabolism in subacute myocardial infarction: a study by means of99mTcsestamibi and123I-beta-methyl-iodo-phenyl pentadecanoic acid.Eur J Nucl Med 21: 283–291, 1994.
Franken PR, Geeter FD, Dendale P, Demoor D, Block P, Bossuyt A. Abnormal free fatty acid uptake in subacute myocardial infraction after coronary thrombolysis: correlation with wall motion and inotropic reserve.J Nucl Med 35: 1758–1765, 1994.
Nakajima K, Shimizu K, Taki J, Uetani Y, Konishi S, Tonami N, et al. Utility of iodine-123-BMIPP in the diagnosis and follow-up of vasospastic angina.J Nucl Med 36: 1934–1940, 1995.
Taki J, Nakajima K, Matsunari I, Bunko H, Takada S, Tonami N. Impairment of regional fatty acid uptake in relation to wall motion and thallium-201 uptake in ischaemic but viable myocardium: assessment with iodine-123-labelled beta-methyl-branched fatty acid.Eur J Nucl Med 22: 1385–1392, 1995.
Matsunari I, Saga T, Taki J, Akashi Y, Hirai J, Wakasugi T, et al. Kinetics of iodine-123-BMIPP in patients with prior myocardial infarction: assessment with dynamic rest and stress images compared with stress thallium-201 SPECT.J Nucl Med 35: 1279–1285, 1994.
Torizuka K, Yonekura Y, Nishimura T, Tamaki N, Uehara T. Phase 2 study of beta-methyl-p-(123I)-iodophenylpentadecanoic acid, a myocardial imaging agent for evaluating fatty acid metabolism.KAKU IGAKU (Jpn J Nucl Med) 29: 305–317, 1992.
Torizuka K, Yonekura Y, Nishimura T, Ohtake T, Bunko H, Tamaki N, et al. Phase 3 study of beta-methyl-p-(123I)iodophenyl-pentadecanoic acid, a myocardial imaging agent for evaluating fatty acid metabolism—a multi-center trial.KAKU IGAKU (Jpn J Nucl Med) 29: 413–433, 1992.
Fujibayashi Y, Yonekura Y, Takemura Y, Wada K, Matsumoto K, Tamaki N, et al. Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), in relation to ATP content.J Nucl Med 31: 1818–1822, 1990.
Fujibayashi Y, Yonekura Y, Kawai C, Yamamoto K, Tamaki N, Konishi J, et al. Basic studies on I-123-beta-methyl-piodophenyl-pentadecanoic acid (BMIPP) for myocardial functional diagnosis: effect of beta-oxydation inhibitor.KAKU IGAKU (Jpn J Nucl Med) 25: 1131–1135, 1988.
Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Magata Y, Torizuka T, et al. Assessment of fatty acid metabolism using I-123 branched fatty acid: Comparison with positron emission tomography.Ann Nucl Med 7: SII-41–SII-47, 1993.
Opie LH. Metabolism of the heart in health and disease.Am Heart J 76: 685, 1968.
Shinmura K, Tani M, Suganuma Y, Hasegawa H, Kawamura M, Nakamura Y, et al.123I-beta-methyl-iodophenyl-pentadecanoic acid myocardial scintigraphy in diabetic patients without overt ischemie heart disease.J Cardiol 26: 23–32, 1995.
Sorrentino D, Stump D, Potter DJ, Robinson RB, White R, Kiang CL, et al. Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.J Clin Invest 82: 928–935, 1988.
Tanaka T, Kawamura K. Isolation of myocardial membrane long-chain fatty acid-binding protein: homology with a rat membrane protein implicated in the binding or transport of long-chain fatty acids.J Mol Cell Cardiol 27: 1613–1622, 1995.
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Hwang, EH., Yamashita, A., Takemori, H. et al. Absent myocardial I-123 BMIPP uptake in a family. Ann Nucl Med 10, 445–448 (1996). https://doi.org/10.1007/BF03164809
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DOI: https://doi.org/10.1007/BF03164809