Skip to main content
SpringerLink
Log in

Evaluation of uptake and release of technetium-99m MIBI SPECT of pulmonary and mediastinal lesions

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

We evaluated the uptake and release of Tc-99m MIBI in 7 benign and 30 malignant pulmonary and mediastinal lesions. Of the 37 patients, 13 underwent surgery; malignant involvement was examined in 21 mediastinal lymph nodes. Tl-201 SPECT was also performed in 10 patients. Tc-99m MIBI SPECT studies were performed on transverse SPECT images acquired 30 minutes and 3 hours after intravenous injection of 600 MBq of Tc-99m MIBI with three gamma camera detectors (GCA-9300A). Regions of interest were set in the area of abnormal uptake of Tc-99m MIBI and in an area of normal tissue in the contralateral lung. The uptake ratio of the lesion in the contralateral normal lung was obtained on the early image (early ratio; ER) as well as the delayed image (delayed ratio; DR). The benign lesions showed significantly lower ER (1.6 ± 0.3) and DR (1.4 ± 0.4) than the malignant lesions (1.9 ± 0.5 and 1.8 ± 0.5, respectively; both p < 0.05). There was no significant difference in the retention index (RI), calculated as RI = (DR − ER)/ER × 100. The DR obtained with Tl-201 SPECT images was significantly higher than that obtained with Tc-99m MIBI SPECT (p < 0.05). For the detection of mediastinal lymph node metastases, the early images showed sensitivity, specificity, and accuracy of 85.7%, 100%, and 95.2%, respectively, for the delayed images these values were 85.7%, 92.9%, and 90.5%, respectively. These results suggest that the uptake ratio of Tc-99m MIBI is a useful index in assessing benign or malignant pulmonary and mediastinal lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Holman BL, Jones AG, Lister-James L, Pavison A, Abrams MJ, Kirshenbaum JM, et al. A new Tc-99m-labeled myocardial imaging agent, hexakis(t-butylisonitrile) technetium(I) [Tc-99m TBI]: initial experience in the human.J Nucl Med 25: 1350–1355, 1984.

    PubMed  CAS  Google Scholar 

  2. Wackers FJ Th, Berman DS, Maddahi J, Beller G, Fridrich R, Delaloye B, et al. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.J Nucl Med 30: 301–311, 1989.

    PubMed  CAS  Google Scholar 

  3. Delmon-Moingeon LI, Piwmica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG. Uptake of the Cation Hexakis(2-methoxyisobutylisonitrile)-Technetium-99m by Human Carcinoma Cell Linesin Vitro.Cancer Res 50: 2198–2202, 1990.

    PubMed  CAS  Google Scholar 

  4. Maublant JC, Zheng Z, Rapp M, Ollier M, Michelot J, Veyre A.In Vitro Uptake of Technetium-99m-Teboroxime in Carcinoma Cell Lines and Normal Cells: Comparison with Technetium-99m-Sestamibi and Thallium-201.J Nucl Med 34: 1949–1952, 1993.

    PubMed  CAS  Google Scholar 

  5. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of Mitochondrial and Plasma Membrane Potentials on Accumulation of Hexakis (2-Methoxyisobutylisonitrile) Technetium (I) in Cultured Mouse Fibroblasts.J Nucl Med 31: 1646–1653, 1990.

    PubMed  CAS  Google Scholar 

  6. Hassan IM, Sahweil A, Constantinides C, Mahmoud A, Nair M, Omar YT. Uptake and Kinetics of Tc-99m Hexakis 2-Methoxy Isobutyl Isonitrile in Benign and Malignant Lesions in the Lungs.Clin Nucl Med 14: 333–340, 1989.

    Article  PubMed  CAS  Google Scholar 

  7. Aktolun C, Bayhan H, Kir M. Clinical Experience with Tc-99m MIBI Imaging in Patients with Malignant Tumors: Preliminary Results and Comparison with Tl-201.Clin Nucl Med 17: 171–176, 1992.

    Article  PubMed  CAS  Google Scholar 

  8. Matsui R, Komori T, Narabayashi I, Namba R, Nakata Y, Tabuchi K, et al. Tc-99m Sestamibi Uptake by Malignant Lymphoma and Slow Washout.Clin Nucl Med 20: 352–356, 1995.

    Article  PubMed  CAS  Google Scholar 

  9. Kao CH, Wang SJ, Lin WY, Hsu CY, Liao SQ, Yeh SH. Differentiation of single solid lesions in the lungs by means of single-photon emission tomography with technetium-99m methoxyisobutylisonitrile.Eur J Nucl Med 20: 249–254, 1993.

    PubMed  CAS  Google Scholar 

  10. Strouse PJ, Wang DC. Incidental Detection of Bronchogenic Carcinoma During Tc-99m SESTAMIBI Cardiac Imaging.Clin Nucl Med 18: 448–449, 1993.

    Article  PubMed  CAS  Google Scholar 

  11. General Rule for Clinical and Pathological Record of Lung Cancer (The 4th edition). Edited by The Japan Lung Cancer Society. Kanahara Shuppan, Tokyo, 1995.

  12. UICC.TNM Classification of Malignant Tumors, 4th edn. Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer, 1987.

    Google Scholar 

  13. Piwnica-Worms D, Holman BL. Noncardiac applications of hexakis(alkylisonitrile)technetium-99m complexes.J Nucl Med 31: 1166–1167, 1990.

    PubMed  CAS  Google Scholar 

  14. Chen LB. Mitochondrial membrane potential in living cells.Ann Rev Cell Biol 4: 155–181, 1988.

    PubMed  CAS  Google Scholar 

  15. Komori T, Matsui R, Adachi I, Shimizu T, Sueyoshi K, Narabayashi I.In Vitro Uptake and Release of201Tl and99mTc-MIBI in HeLa Cell.Jpn J Nucl Med 32: 651–658, 1995.

    CAS  Google Scholar 

  16. Muriel DC, Anna S, Laurence DM, Caroline B, Jean-Claude K, Grégoire P, et al. Technetium-99m-Sestamibi Uptake by Human Benign and Malignant Breast Tumor Cells: Correlation with mdr Gene Expression.J Nucl Med 37: 286–289, 1996.

    Google Scholar 

  17. Arturo C, Lorenzo SM, Maurizio I, Giancomo G, Matteo I, Massimo DG, et al. Assessment of Mediastinal Involvement in Lung Cancer with Technetium-99m-Sestamibi SPECT.J Nucl Med 37: 938–942, 1996.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, Takatsuki, 569, Osaka, Japan

    T. Komori, I. Narabayashi, R. Matsui, Y. Tatsu, K. Sueyoshi, I. Adachi, T. Shimizu, R. Namba & Y. Nakata

Authors
  1. T. Komori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Narabayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Matsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Tatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Sueyoshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R. Namba
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Y. Nakata
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Komori, T., Narabayashi, I., Matsui, R. et al. Evaluation of uptake and release of technetium-99m MIBI SPECT of pulmonary and mediastinal lesions. Ann Nucl Med 11, 227–232 (1997). https://doi.org/10.1007/BF03164768

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03164768

Key words

Search

Navigation