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Assessment of area at risk and efficacy of treatment in patients with acute coronary syndrome using99mTc tetrofosmin imaging in humans

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Abstract

The determination of the myocardium at risk before intervention and the change in that region after intervention constitute a promising measurement tool for the assessment of acute therapy. A new99mTc labeled myocardial blood flow tracer,99mTc tetrofosmin, is expected to enable the evaluation of myocardium at risk because of the absence of redistribution. This preliminary study was performed in 9 patients with acute coronary syndrome (4 unstable angina and 5 acute myocardial infarction) to investigate whether recovery of perfusion by tetrofosmin imaging parallels mechanical improvement. Tetrofosmin imaging was performed acutely and 3–30 days later. Visual analysis of defect severity was assessed in both studies. Segments with improvement in perfusion were accompanied by significant wall motion recovery compared with normal and unimproved segments (Δ WMI: normal segments 0.40±0.67, improved segments 1.79±0.68, unimproved segments −0.15±0.16, p< 0.01 for improved segments compared with other groups), suggesting the efficacy of this tracer for the assessment of the acute therapy. These data suggest that99mTc tetrofosmin imaging is a useful method for the assessment of the myocardial area at risk and the efficacy of acute therapy in acute myocardial infarction and unstable angina.

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Authors and Affiliations

  1. Division of Cardiology and Nephrology, Department of Internal Medicine, Japan

    Hitoshi Matsuo, Sachiro Watanabe, Yoshio Nishida, Tetsuo Matsubara, Motoo Kano, Akira Sugiyama, Yukihiko Matsuno, Hiroshi Oda, Yasunori Kotoo & Hiroshige Oohashi

  2. Department of Radiology, Gifu Prefectural Hospital, Japan

    Akira Goto, Kazunari Makita, Hiroshi Watanabe, Taketoshi Mizutani & Hiroshi Miyake

  3. Department of Radiology, Gifu University, School of Medicine, Japan

    Takeyoshi Imaeda

Authors
  1. Hitoshi Matsuo
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  2. Sachiro Watanabe
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  3. Yoshio Nishida
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  4. Tetsuo Matsubara
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  5. Motoo Kano
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  6. Akira Sugiyama
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  7. Yukihiko Matsuno
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  8. Hiroshi Oda
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  9. Yasunori Kotoo
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  10. Hiroshige Oohashi
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  11. Akira Goto
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  12. Kazunari Makita
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  13. Hiroshi Watanabe
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  14. Taketoshi Mizutani
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  15. Hiroshi Miyake
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  16. Takeyoshi Imaeda
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Matsuo, H., Watanabe, S., Nishida, Y. et al. Assessment of area at risk and efficacy of treatment in patients with acute coronary syndrome using99mTc tetrofosmin imaging in humans. Ann Nucl Med 7, 231–238 (1993). https://doi.org/10.1007/BF03164703

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  • DOI: https://doi.org/10.1007/BF03164703

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