Abstract
To evaluate bone metastasis from hepatocellular carcinoma (HCC), both bone and99mTc-HM-PAO scintigraphies were performed in six patients with clinically and pathologically confirmed HCC. Two patients had a bone scintigram which revealed abnormal accumulation in the skull base, pelvic bone and thoracic spine. The99mTc-HM-PAO scans of both these patients also showed abnormal accumulation in the same sites. The bone scintigrams in one patient revealed not only abnormal accumulation in the ribs but also photon deficient areas in the sternum, thoracic spine and femur, while99mTc-HM-PAO scans showed abnormal accumulation in all these sites. In three patients, bone scintigraphy revealed photon deficient areas in the ribs, pelvic bone and femur, and their99mTc-HM-PAO scintigrams showed abnormal accumulation in the same sites. Thus, it was shown that, in the detection of bone metastasis from HCC by means of bone scintigraphy, it was necessary to pay attention to hot and cold lesions, and that a combination study with99mTc-phosphorous compounds and99mTc-HM-PAO was useful in evaluating these lesions.
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Osmond JD, Pendergrass HP, Potsaid MS: Accuracy of99mTc-diphosphonate bone scans and roentgenograms in the detection of prostate, breast and lung carcinoma metastases.Am J Roentgenol Radium Ther Nucl Med 125: 972–977, 1975
Sy WM, Patel K, Faunce H: Significance of absent or faint kidney sign on bone scan.J Nucl Med 16: 454–456, 1975
Thrupkaew AK, Henkin RE, Quinn JL: False negative bone scans in disseminated metastatic disease.Radiology 113: 383–386, 1974
Francis MD, Russel RGG, Fleisch H: Diphosphonates inhibit formation of calcium phosphate crystalsin vitro and pathological calcificationin vivo.Science 165: 1264–1266, 1969
Guillemart A, Besnard JC, Pape AL, et al: Skeletal uptake of pyrophosphate labeled with technetium-95m and technetium-96, as evaluated by autoradiography.J Nucl Med 19: 895–899, 1978
Otsuka N, Morita R, Yamamoto T, et al: A case of synovial sarcoma with bone metastasis identified by bone marrow scintigraphy.Clin Nucl Med 10: 260–263, 1985
Otsuka N, Fukunaga M, Morita K, et al: Detection of bone metastasis from thyroid cancer by bone and201Tl scintigraphy.Endocr Surg 7: 411–416, 1990
Otsuka N, Fukunaga M, Sone T, et al: The usefulness of bone and bone-marrow scintigraphy in the detection of bone involvement in patients with multiple myeloma.Kawasaki Med J 12: 117–124, 1986
Patricia LT, David C, Ali TI, et al: Photon deficient bone metastasis of hepatocellular carcinoma with avid gallium-67 uptake.J Nucl Med 26: 1415–1417, 1985
Hoshi H, Jinnouchi S, Sameshima M, et al: Tc-99m hexamethylpropylene-amine oxime (HM-PAO) up-take in a bone metastasis.Clin Nucl Med 13: 595–598, 1988
Hasegawa Y, Nakano S, Ibuka K, et al: Concentration of99mTc-Sn-N-pyridoxyl-5-methyltryptophan, a biliary agent, in distant metastases of hepatomas.Eur J Nucl Med 10: 255–258, 1985
Borak J: Relationship between the clinical and roentgenological findings in bone metastasis.Surg Gynecol Obstet 75: 599–604, 1942
Hammersley PAG, McCready VR, Babich JW, et al:99mTc-HM-PAO as a tumor blood flow agent.Eur J Nucl Med 13: 90–94, 1987
Fujii H, Hashimoto T, Nakamura K, et al: Tumor imaging using99mTc-hexamethylpropyleneamine oxime.Jpn J Nucl Med 27: 249–260, 1990
Cornelia G, Hossein F, Mahvash R: Hepatocellular carcinoma with skeletal metastasis.Radiology 154: 617–618, 1985
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This study was supported in part by a Research Project Grant (No. 1-801) from Kawasaki Medical School.
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Otsuka, N., Fukunaga, M., Morita, K. et al. Accumulation of99mTc-HM-PAO in photon deficient areas in bone scan of bone metastasis from hepatocellular carcinoma. Ann Nucl Med 6, 215–220 (1992). https://doi.org/10.1007/BF03164657
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DOI: https://doi.org/10.1007/BF03164657