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Variations in radioimmunoscintigraphic detection of tumor showed by five monoclonal antibodies to carcinoembryonic antigen

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Abstract

Radioimmunoscintigraphy using mouse monoclonal antibodies to various parts of a carcinoembryonic antigen (CEA) molecule was performed. Four radiolabeled antibodies (F4–82, 28A, F3–30, F33–104) were injected into tumor transplanted nude mice to compare the accumulation of these antibodies in tumors. The four antibodies were accumulated selectively in CEA-producing tumors. The tumor visualization correlated with the tumor/blood radioactivity ratio, whereas the tumor/blood radioactivity ratio did not correlate with thein vitro percent binding to tumor cells or thein vivo percent injected dose in CEA-producing tumors. Among the four antibodies, F33–104 showed the highest tumor/blood radioactivity ratio and the best image quality in any CEA-producing tumor. These results suggest that the antibody which has a high tumor/blood ratio rather than high total tumor uptake may be useful for radioimmunoscintigraphy.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, 852, Nagasaki, Japan

    Kenji Kohno, Keisuke Nakata, Yukio Kusumoto & Shigenobu Nagataki

  2. Health Center of Nagasaki University, Japan

    Nobuko Ishii & Toshihiko Komi

  3. The First Department of Biochemistry, Fukuoka University School of Medicine, Japan

    Yuji Matsuoka

  4. TheFirst Department of Biochemistry, Hokkaido University School of Medicine, Japan

    Shinzo Nishi

Authors
  1. Kenji Kohno
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  2. Keisuke Nakata
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  3. Yukio Kusumoto
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  4. Nobuko Ishii
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  5. Toshihiko Komi
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  6. Yuji Matsuoka
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  7. Shinzo Nishi
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  8. Shigenobu Nagataki
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Kohno, K., Nakata, K., Kusumoto, Y. et al. Variations in radioimmunoscintigraphic detection of tumor showed by five monoclonal antibodies to carcinoembryonic antigen. Ann Nucl Med 5, 69–75 (1991). https://doi.org/10.1007/BF03164617

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  • DOI: https://doi.org/10.1007/BF03164617

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