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Positron emission tomography using pyruvate-l-11C in two cases of mytochondrial encephalomyopathy

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Abstract

Positron emission tomography (PET) using pyruvate-l-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh’s disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of the epileptic patients soon after injection of pyruvate-l-11C. PET images of mitochondrial encephalomyopathy patients showed an increase in radioactivity in the cerebral cortex, basal ganglia and thalamus, with elimination of radioactivity being slower than that of epileptic patients. One patient with Leigh’s disease showed similar PET images. PET using pyruvate-1-11C is useful for the evaluation of mitochondrial energy metabolism in the brain.

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Authors and Affiliations

  1. Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, 4-1-1, Ogawahigashi-cho, Kodaira, 187, Tokyo, Japan

    Momozou Toyoda, Norio Sakuragawa, Yukio Arai, Hideto Yoshikawa, Kenji Sugai & Masataka Arima

  2. National Center of Neurology and Psychiatry, Japan

    Eijiro Satoyoshi

  3. National Nakano Chest Hospital, Japan

    Toshihiko Hara & Masaaki Iio

Authors
  1. Momozou Toyoda
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  2. Norio Sakuragawa
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  3. Yukio Arai
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  4. Hideto Yoshikawa
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  5. Kenji Sugai
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  6. Masataka Arima
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  7. Toshihiko Hara
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  8. Masaaki Iio
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  9. Eijiro Satoyoshi
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Toyoda, M., Sakuragawa, N., Arai, Y. et al. Positron emission tomography using pyruvate-l-11C in two cases of mytochondrial encephalomyopathy. Ann Nucl Med 3, 103–109 (1989). https://doi.org/10.1007/BF03164593

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  • DOI: https://doi.org/10.1007/BF03164593

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