Zusammenfassung
Hintergrund
Ziel der Arbeit war es, die Verteilung der Somatostatinrezeptor-Subtypen 2, 3 und 5 in uvealen Melanomen zu eruieren.
Methodik
Somatostatinrezeptoren (SSt) wurden in 25 mit Formaldehyd fixierten Augen mit uvealem Melanom mittels polyklonalem Antiserum gegen SSt der Subtypen 2 A, 2 B, 3 und 5 lokalisiert. Die Antigen-Expression wurde mittels einer semiquantitativen Methode gemessen.
Resultate
SSt 2 wurde in allen uvealen Melanomen gefunden wobei 2 A in 15 von 25 und 2 B in 23 von 25 exprimiert wurde. SSt 3 war in 7 von 25 und SSt 5 in 14 von 25 Fällen positiv.
Diskussion
Somatostatinrezeptoren 2, 3, und 5 werden in uvealen Melanomen exprimiert. Dieses Phänomen könnte in der Diagnose und Therapie des uvealen Melanoms eine bedeutende Rolle einnehmen.
Summary
Purpose
To investigate the distribution of somatostatin receptor subtypes 2, 3, and 5 in uveal melanomas.
Methods
Somatostatin receptors (SSt) were investigated in twenty-five paraffin embedded eyes with uveal melanomas using polyclonal antiserum directed to SSt 2 A, 2 B, 3 and 5. Antigen expression was evaluated using a semiquantitative method.
Results
SSt 2 was found to be positive in all uveal melanomas, whereas SSt 2 A was expressed in 15/25 and SSt 2 B in 23/25 cases. SSt 3 was positive in 7/25 and SSt 5 in 14/25 melanomas.
Conclusion
Somatostatin receptors 2, 3 and 5 are expressed in uveal melanomas. This phenomenon could play a crucial role in the diagnosis and treatment of uveal melanomas.
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Fellner, P., El-Shabrawi, Y. & Ardjomand, N. Somatostatinrezeptor Expression in uvealen Melanomen. Spektrum Augeheilkd 16, 211–213 (2002). https://doi.org/10.1007/BF03164336
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DOI: https://doi.org/10.1007/BF03164336