Zusammenfassung
Massive submakuläre Blutungen bei chorioidaler Neovaskularisation im Rahmen einer altersbedingten Makuladegeneration stellen für die betroffenen Patienten ein katastrophales Ereignis dar.
Wir haben die Inzidenz solcher Hämorrhagien nach photodynamischer Therapie mit Verteporfin untersucht und systemische Risikofaktoren, welche das Auftreten einer submakulären Blutung begünstigen könnten, evaluiert.
Nach photodynamischer Therapie kommt es innerhalb von 7 Tagen in 0,5–4,9% zu einer massiven submakulären Hämorrhagie, die Häufigkeit in der Kontrollgruppe liegt unter 1%.
Eine Cumarintherapie begünstigt das Auftreten einer ausgedehnten submakulären Blutung, für andere systemische Faktoren konnte kein signifikantes Risiko festgestellt werden.
Summary
Massive submacular bleedings associated with choroidal neovascularisation in age-related macular degeneration mark a catastrophic event for the affected patient.
We investigated the incidence of such haemorrhages after photodynamic therapy with verteporfine and evaluated systemic risk factors suspected of promoting submacular bleedings.
Within 7 days after photodynamic therapy 0.5–4.9% of patients experience a massive submacular haemorrhage, the frequency in the control group is below 1%.
Warfarin therapy faciliates the development of extensive submacular bleedings, no significant risk could be found for other systemic factors.
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Radda, S.M., Brandstetter, M., Michl, R. et al. Komplikation nach PDT: Massive submakuläre Blutung. Spektrum Augenheilkd 18, 196–197 (2004). https://doi.org/10.1007/BF03163600
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DOI: https://doi.org/10.1007/BF03163600