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Cerebral ischemic injury model of rat demonstrated withT 2-weighted magnetic resonance imaging

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Abstract

A photochemical reaction model of focal cerebral ischemic injury of rat was demonstrated by means of enhancedT 2-weighted magnetic resonance imaging. The cerebral ischemia model was made using vein injection of rose bengal and irradiation by a beam of a cw laser with the wave-length of 514 nm. The ischemic injury region in rat brain can be found clearly in theT 2-weighted magnetic resonance images in one hour, this time was calculated from the beginning of the laser irradiation to the end of the NMR data acquisition. It suggests thatT 2-weighted imaging can find cerebral ischemia earlier than several hours after the onset of ischemia given in other papers. It also confirms that theT 2-weighted magnetic resonance imaging approach should be of great potential to be applied in studying the cerebral ischemia.

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Authors and Affiliations

  1. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People’s Republic of China

    G. L. Ding, H. B. Hu, L. Y. Li & C. H. Ye

  2. Union Hospital, Tongji Medical University, Wuhan, People’s Republic of China

    J. W. Zhang & E. T. Tong

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  1. G. L. Ding
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  2. H. B. Hu
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  3. L. Y. Li
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  4. C. H. Ye
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  5. J. W. Zhang
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  6. E. T. Tong
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Ding, G.L., Hu, H.B., Li, L.Y. et al. Cerebral ischemic injury model of rat demonstrated withT 2-weighted magnetic resonance imaging. Appl. Magn. Reson. 15, 503–508 (1998). https://doi.org/10.1007/BF03162032

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  • DOI: https://doi.org/10.1007/BF03162032

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