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Selective detection of13C-containing metabolites by1H double-resonance BLISS sequence

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Abstract

Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as13C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing1H-observed/13C-editing double resonance techniques, based on intermolecular short-rangeJ-coupling interaction, is the nontotal proton solvent elimination. The indirect13C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.

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Authors and Affiliations

  1. Dipartimento di Fisica, Università “La Sapienza”, Rome, Italy

    S. Capuani, L. Mancini & B. Maraviglia

  2. Istituto Nazionale di Fisica della Materia, Rome, Italy

    S. Capuani, L. Mancini & B. Maraviglia

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  1. S. Capuani
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  2. L. Mancini
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  3. B. Maraviglia
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Capuani, S., Mancini, L. & Maraviglia, B. Selective detection of13C-containing metabolites by1H double-resonance BLISS sequence. Appl. Magn. Reson. 15, 383–391 (1998). https://doi.org/10.1007/BF03162023

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  • DOI: https://doi.org/10.1007/BF03162023

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