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Alteration of electrophysiological function of isolated retina from alloxan-induced diabetic rats: Effect of treatment withGinkgo biloba extract

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Neurochemical Pathology

Abstract

In the first stage the authors highlight the functional impairments owing to diabetic retinopathy by performing experiments on isolated retinas of alloxan-induced diabetic rats. After 1 mo evolution of diabetes, the electroretinograms (ERG) obtained on isolated retinas had an amplitude on average 20% lower than the controls, whereas after 2 mo of diabetes, this decrease in amplitude is around 60%.

In the second stage, the authors compare the electroretinograms obtained on the isolated retina of 2 mo diabetic animals, nontreated or treated per os withGinkgo biloba extract (100 mg/kg/d): These ERG have a significantly greater amplitude (p<0.001) in treated animals. The results are discussed in relation to the role of oxygenated free radicals in diabetic retinopathy, the production of these induced by platelet-activating factor (PAF), and the PAF antagonistic properties ofGinkgo biloba extract, which could participate in the preventive treatment of the visual functional impairments involved in diabetes.

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Authors and Affiliations

  1. Laboratoire de Biophysique, Facultés de Médecine et de Pharmacie, B.P. 38, 63001, Clermont-Ferrand, France

    Michel Doly, Pierre Braquet, Marie-Thérèse Droy, Brigitte Bonhomme, Marie-Madeleine Ruchoux & Gaston Meyniel

  2. Institut Henri Beaufour Research Laboratories, Le Plessis-Robinson, France

    Michel Doly, Pierre Braquet, Marie-Thérèse Droy, Brigitte Bonhomme, Marie-Madeleine Ruchoux & Gaston Meyniel

  3. Laboratoire de Neuropathologie (Pr. Autret) CHU, Tours, France

    Michel Doly, Pierre Braquet, Marie-Thérèse Droy, Brigitte Bonhomme, Marie-Madeleine Ruchoux & Gaston Meyniel

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  1. Michel Doly
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  2. Pierre Braquet
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  3. Marie-Thérèse Droy
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  4. Brigitte Bonhomme
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  5. Marie-Madeleine Ruchoux
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  6. Gaston Meyniel
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Doly, M., Braquet, P., Droy, MT. et al. Alteration of electrophysiological function of isolated retina from alloxan-induced diabetic rats: Effect of treatment withGinkgo biloba extract. Neurochemical Pathology 8, 15–26 (1988). https://doi.org/10.1007/BF03160132

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  • DOI: https://doi.org/10.1007/BF03160132

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