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The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema

  • Original Articles
  • Published:
Molecular and Chemical Neuropathology

Abstract

Results of our consecutive study on the pathogenetic mechanism underlying ischemic brain edema are summarized in this paper. Pertinent findings are as follows: (1) there is a close correlation between the influxes of water and sodium following ischemia; (2) the edema fluid can be regarded as the ultrafiltrate of serum; (3) there is a significant increase in the brain content of HETEs following ischemia; (4) the lipoxygenase activity of brain microvessels is increased following ischemia; (5) the lipoxygenase activity as well as the Na+, K+-ATPase activity of brain microvessels are enhanced by a hydroperoxide, 15-HPETE; (6) inhibition of Na+,K+-ATPase of brain microvessels by intraarterial infusion of ouabain resulted in a significant decrease in edema formation; and (7) not the cyclooxygenase, but the lipoxygenase pathway seems to be involved in the enhancement of microvessel Na+,K+-ATPase.

Lipoxygenase(s) and Na+−K+-ATPase of brain microvessels, the activities of which are enhanced by an increased level of free radicals and/or hydroperoxides, may play a significant role in the occurrence of ischemic brain edema.

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Authors and Affiliations

  1. Department of Neurosurgery, Saitama Medical Center, Saitama Medical School, 1981 Kamota, 350, Kawagoe, Saitama, Japan

    Takao Asano, Hiroo Joshita & Taku Shigeno

  2. Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan

    Tohru Koide, Osamu Gotoh, Tetsu Hanamura & Kintomo Takakura

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  1. Takao Asano
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  2. Tohru Koide
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  3. Osamu Gotoh
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Asano, T., Koide, T., Gotoh, O. et al. The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema. Molecular and Chemical Neuropathology 10, 101–133 (1989). https://doi.org/10.1007/BF03159717

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