Skip to main content
SpringerLink
Log in

Fifty years of cardiac pacing: the dark side of the moon?

  • article
  • Published:
Netherlands Heart Journal Aims and scope Submit manuscript

Abstract

Fifty years after its introduction, cardiac pacing has evolved from an experimental medical treatment to an expanding field in today's cardiology. Only recently there is accumulating evidence that prolonged stimulation of the right ventricular apex is associated with clinically significant adverse effects. In this commentary, the potential adverse effects are summarised and potential modifications in contemporary pacing are discussed. (Neth Heart J 2008;16(suppl 1):S12-S14.)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Report of the World Health Organization (WHO): World health statistics 2008. ISBN 978 92 4 156359 8 (NLM classification: WA 900.1).

  2. Maisel W, Moynahan M, Zuckerman B, Gross T, Tovar O, Tillmann D, et al. Pacemaker and ICD generator malfunctions. Analysis of Food and Drug Administration annual report. JAMA 2006;295:1901-6.

    Google Scholar 

  3. Wiggers CJ. The muscular reactions of the mammalian ventricles to artificial surface stimuli. Am J Physiol 1925;37C:275-82.

    Google Scholar 

  4. Tse HF, Lau CP. Long-term effect of right ventricular pacing on myocardial perfusion and function. J Am Coll Cardiol 1997;29: 744-9.

    Google Scholar 

  5. Tantengco MV,Thomas RL, Karpawich PP. Left ventricular dysfunction after long-term right ventricular apical pacing in the young, J Am Coll Cardiol 2001;37:2093-100.

    Google Scholar 

  6. Connolly SJ, Kerr CR, Gent M, Roberts R, Yusuf S, Gillis AM, et al. Canadian Trial of Physiologic Pacing Investigators, Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. N Engl J Med 2000;342:1385-91.

    Google Scholar 

  7. Lamas GA, Lee KL, Sweeney MO, Silverman R, Leon A, Yee R, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med 2002;346:1854-62.

    Google Scholar 

  8. Sweeney MO, Hellkamp AS, Ellenbogen KE, Greenspon AJ, Freedman RA, Lee KL, et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation 2003;107:2932-7.

    Google Scholar 

  9. The DAVID Trial Investigators. Dual-chamber pacing or ventricular backup pacing in patients with an implantble defibrillator: The Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA 2002;288:3115-23.

    Google Scholar 

  10. Steinberg JS, Fischer A, Wang P, Schuger C, Daubert C, McNitt S, et al. The clinical implications of cumulative ventricular pacing in the Multicenter Automatic Defibrillator Trial (MADIT II). J Cardiovasc Electrophysiol 2005;16:359-65.

    Google Scholar 

  11. Nielsen JC, Pedersen AK, Mortensen PT, Pedersen OL, Pedersen AK, et al. Programming a fixed long atrioventricular delay is not effective in preventing ventricular pacing in patients with sick sinus syndrome. Europace 1999;1:113-20.

    Google Scholar 

  12. Sweeney MO, Shea JB, Fox V. Randomized trial of a new atrial-based minimal ventricular pacing mode in dual chamber implantable cardioverter-defibrillators: MVP. Heart Rhythm 2004;1:60-7.

    Google Scholar 

  13. Sweeney MO, Bank AJ, Nsah E. Koullick M, Zeng QC, Hettrick D, et al. Minimizing ventricular pacing to reduce atrial fibrillation in sinus-node disease. N Engl J Med 2007;357:1000-8.

    Google Scholar 

  14. Deshmukh P, Casavant DA, Romanyshyn M, Anderson K. Permanent, direct His-bundle pacing, a novel approach to cardiac pacing in patients with normal His-Purkinje activation. Circulation 2000;101:869-77.

    Google Scholar 

  15. de Cock CC, Giudici MC, Twisk JW. Comparison of the haemo-dynamic effects of right ventricular outflow-tract pacing with right ventricular apex pacing. Europace 2003;5:275-8.

    Google Scholar 

  16. Giudici MC, Karpawich PP. Alternative pacing sites: it's time to define terms. Pacing Clin Cardiol 1999;22:551-3.

    Google Scholar 

  17. Lieberman R, Padeletti L, Schreuderr J, Jackson K. Michelucci A, Colella A, et al. Ventricular pacing lead position alters systemic hemodynamics and left ventricular function in patients with and without reduced ejection fraction. J Am Coll Cardiol 2006;48:1634-41.

    Google Scholar 

  18. Varma C, O'Callaghan P, Mahon NG, Hnatkova K, McKenna W, Camm AJ, et al. Effects of multisite pacing on ventricular coordination. Heart 2002;87:322-8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. www.bsl.nl/shop/

    C. C. de Cock

Authors
  1. C. C. de Cock
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. C. de Cock.

Additional information

Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands

N.M. van Hemel Professor Emiritus, Utrecht University, Utrecht, the Netherlands

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Cock, C.C. Fifty years of cardiac pacing: the dark side of the moon?. NHJL 16, 10–12 (2008). https://doi.org/10.1007/BF03086198

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03086198

Search

Navigation