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Rapid oral desensitisation procedure in clopidogrel hypersensitivity

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Abstract

We describe a patient who developed generalised pruritis with oedema and rash two weeks after she had started taking clopidogrel following coronary stent implantation. In the absence of other likely causative agents, clopidogrel hypersensitivity was probable. She was treated with a rapid oral desensitisation procedure, after which a daily dose of 75 mg clopidogrel was well tolerated. No major adverse events occurred during a follow-up period of eight months. Oral desensitisation in clopidogrel hypersensitivity seems to be a safe method to reduce the risk of coronary stent thrombosis. (Neth Heart J 2008;16:21-3).

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    B. Oppedijk

Authors
  1. B. Oppedijk
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  2. D. A. M. Odekerken
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  3. J. J. van der Wildt
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  4. C. F. Melissant
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Corresponding author

Correspondence to B. Oppedijk.

Additional information

Department of Cardiology, Spaarne Hospital, Hoofddorp, the Netherlands

Department of Cardiology, Spaarne Hospital, Hoofddorp, the Netherlands

Clinical Pharmacy, Spaarne Hospital, Hoofddorp, the Netherlands

Department of Pulmonary Medicine, Spaarne Hospital, Hoofddorp, the Netherlands

B. Oppedijk Department of Cardiology, Spaarne Hospital, PO Box 770, 2130 AT Hoofddorp, the Netherlands

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Oppedijk, B., Odekerken, D.A.M., van der Wildt, J.J. et al. Rapid oral desensitisation procedure in clopidogrel hypersensitivity. NHJL 16, 21–23 (2008). https://doi.org/10.1007/BF03086112

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  • DOI: https://doi.org/10.1007/BF03086112

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