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De langetermijngevolgen van mdma-gebruik op het serotonerge systeem, het werkgeheugen en impulsiviteit

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Neuropraxis

Samenvatting

3,4-methyleendioxymethamfetamine (mdma), ook wel xtc of ecstasy genoemd, is een populaire recreatieve drug (De Win et al., 2005; Jellinek, 2007). Er bestaan vermoedens dat het gebruik op de lange termijn schadelijke gevolgen heeft voor het serotonerge systeem en daarmee op fysiek, emotioneel en cognitief gebied (Gouzoulis-Mayfrank & Daumann, 2006a, McCann et al., 2008; Thomasius et al., 2006). Het mdma-onderzoek kent een aantal complicerende factoren van grotendeels methodologische aard, die zijn besproken in Neuropraxis 4, 2009, 83-88. Dit artikel beperkt zich tot een analyse van de gevolgen op lange termijn, vanaf een aantal maanden, van mdma-gebruik op de serotoninehuishouding en twee cognitieve aspecten: werkgeheugen en impulsiviteit.

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Literatuur

  • Allen, P.P., Cleare, A.J., Lee, F., Fusar-Poli, P., Tunstall, N., Fu, C. H. et al. (2006). Effect of acute tryptophan depletion on pre-frontal engagement. Psychopharmacology (Berlijn), 187,4, 486-497.

  • Ashcraft, M.H. (2002). Cognition (3 ed.). New Jersey: Pearson Education.

  • Back-Madruga, C., Boone, K.B., Chang, L., Grob, C.S., Lee, A., Nations, H. et al. (2003). Neuropsychological effects of 3,4-methylenedioxymethamphetamine (mdma or ecstasy) in recreational users. Clinical Neuropsychology, 17,4, 446-459.

  • Bedi, G. & Redman, J. (2008). Psychological Medicine, 38, 1319–1330.

    Google Scholar 

  • Bogt, T. F. ter & Engels, R.C. (2005). ‘Partying’ hard: party style, motives for and effects of mdma use at rave parties. Substance Use & Misuse, 40,9-10, 1479-1502.

    Google Scholar 

  • Buchert, R., Schulze, O., Wilke, F., Berding, G., Thomasius, R., Petersen, K. et al. (2006). Is correction for age necessary in spect or pet of the central serotonin transporter in young, healthy adults? Journal of Nuclear Medicine, 47,1, 38-42.

    Google Scholar 

  • Buchert, R., Thomasius, R., Nebeling, B., Petersen, K., Obrocki, J., Jenicke, L. et al. (2003). Long-term effects of ‘ecstasy’ use on serotonin transporters of the brain investigated by pet. Journal of Nuclear Medicine, 44,3, 375-384.

    Google Scholar 

  • Buchert, R., Thomasius, R., Wilke, F., Petersen, K., Nebeling, B., Obrocki, J. et al. (2004). A voxel-based pet investigation of the long-term effects of ‘Ecstasy’ consumption on brain serotonin transporters. American Journal of Psychiatry, 161,7, 1181-1189.

    Google Scholar 

  • Chamberlain, S.R., Muller, U., Robbins, T. W. & Sahakian, B. J. (2006). Neuropharmacological modulation of cognition. Current Opinion in Neurology, 19,6, 607-612.

    Google Scholar 

  • Clark, L., Roiser, J.P., Robbins, T.W. & Sahakian, B.J., (2009). Disrupted ‘reflection’ impulsivity in cannabis users but not current or former ecstasy users. Journal of Psychopharmacology, 23,1, 14-22.

    Google Scholar 

  • Clemens, K.J., McGregor, I.S., Hunt, G.E., & Cornish, J.L. (2007). mdma, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. Drug and Alcohol Review, 26,1, 9-15.

    Google Scholar 

  • Cowan, R.L. (2007). Neuroimaging research in human mdma users: a review. Psychopharmacology (Berlijn), 189,4, 539-556.

    Google Scholar 

  • Cowan, R.L., Haga, E., de, B.F.B., Dietrich, M.S., Vimal, R.L., Lukas, S.E. et al. (2006). mdma use is associated with increased spatial bold fmri visual cortex activation in human mdma users. Pharmacology Biochemistry and Behavior, 84,2, 219-228.

  • Dafters, R.I. (2006). Impulsivity, inhibition and negative priming in ecstasy users. Addictive Behaviors, 31,8, 1436-1441.

    Google Scholar 

  • Daumann, J., Jr., Fischermann, T., Heekeren, K., Thron, A. & Gouzoulis-Mayfrank, E. (2004). Neural mechanisms of working memory in ecstasy (mdma) users who continue or discontinue ecstasy and amphetamine use: evidence from an 18-month longitudinal functional magnetic resonance imaging study. Biological Psychiatry, 56,5, 349-355.

  • De Sola Llopis, S., Miguelez-Pan, M., Peña-Casanova, J., Poudevida, S., Farré, M., Pacifici, R., Böhm, P., Abanades, S., Verdejo García, A., Langohr, K., Zuccaro P. & de la Torre, R.(2008). Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Journal of Psychopharmacology, 22, 498-510.

  • Devlin, H. (2007). Introduction to fmri. http://www.fmrib.ox.ac.uk/resources/education/fmri/introduction-to-fmri/.

  • Frei, E., Gamma, A., Pascual-Marqui, R., Lehmann, D., Hell, D. & Vollenweider, F. X. (2001). Localization of mdma-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (loreta). Human Brain Mapping, 14,3, 152-165.

  • Fox, H.C., McLean, A., Turner, J.J., Parrott, A.C., Rogers, R. & Sahakian, B.J. (2002). Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free mdma (‘ecstasy’) polydrug users. Psychopharmacology (Berlijn), 162,2, 203-214.

  • Gazzaniga, M.S., Ivry, R.B., Mangun, G.R. (2002). Cognitive Neuroscience: The Biology of the Mind (2 ed.). New York: W. W. Norton & Company.

  • Gouzoulis-Mayfrank, E. & Daumann, J. (2006a). Neurotoxicity of methylenedioxyamphetamines (mdma; ecstasy) in humans: how strong is the evidence for persistent brain damage? Addiction, 101,3, 348-361.

  • Gouzoulis-Mayfrank, E. & Daumann, J. (2006b). The confounding problem of polydrug use in recreational ecstasy/mdma users: a brief overview. Journal of Psychopharmacology, 20,2, 188-193.

    Google Scholar 

  • Gouzoulis-Mayfrank, E., Thimm, B., Rezk, M., Hensen, G. & Daumann, J. (2003). Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users. Progress in Neuro-psychopharmacology and Biological Psychiatry, 27,5, 819-827.

    Google Scholar 

  • Green, A.R., Mechan, A.O., Elliott, J.M., O’Shea, E. & Colado, M.I. (2003). The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (mdma, ‘ecstasy’). Pharmacological Reviews, 55,3, 463-508.

  • Han, D.D., & Gu, H.H. (2006). Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. bmc Pharmacology, 6, 6.

  • Hanson, K.L., Luciana, M. & Sullwold, K.(2008). Reward-related decision-making deficits and elevated impulsivity among mdma and other drug users. Drug and Alcohol Dependence, 96,1-2, 99-110.

    Google Scholar 

  • Jacobsen, L.K., & Mencl, W. (2004). Preliminary evidence of hippocampal dysfunction in adolescent mdma (‘ecstasy’) users: possible relationship to neurotoxic effects. Psychopharmacology (Berlijn), 173,3-4, 383-390.

    Google Scholar 

  • Jager, G, Win, M.M.L. de, Tweel, I. van der, Schilt, T., Kahn, R.S., Brink, W. van den, Ree, J.M. van & Ramsey, N.F. (2007). Assessment of cognitive brain function in ecstasy users and contributions of other drugs of abuse: results from an fmri study. Neuropsychopharmacology, 33,2, 247-258.

  • Jellinek (2007). xtc. http://www.jellinek.nl/drugsvoorlichting/matrix-sub.php?m=drugsvoorlichting&r=2&s=5

  • McCann, U. D., Szabo, Z., Seckin, E., Rosenblatt, P., Mathews, W. B., Ravert, H. T., et al. (2005). Quantitative pet studies of the serotonin transporter in mdma users and controls using [11C]McN5652 and [11C]DASB. Neuropsychopharmacology, 30(9), 1741-1750.

    Google Scholar 

  • McCann, U.D., Szabo, Z., Vranesic, M., Palermo, M., Mathews, W.B., Ravert, H.T., Dannals, R.F. & Ricaurte, G.A. (2008). Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent 3, 4-methylenedioxymethamphetamine (‘ecstasy’) users: relationship to cognitive performance. Psychopharmacology, 200,3, 439-450.

  • Moeller, F.G., Steinberg, J.L., Dougherty, D.M., Narayana, P. ., Kramer, L.A., & Renshaw, P.F. (2004). Functional mri study of working memory in mdma users. Psychopharmacology (Berlijn), 177,1-2, 185-194.

  • Montgomery, C., Fisk, J.E., Newcombe, R., Wareing, M. & Murphy, P.N. (2005). Syllogistic Reasoning Performance in mdma (Ecstasy) Users. Experimental and Clinical Pharmacology, 13,2, 137-45

    Google Scholar 

  • Mowla, A., Mosavinasab, M. & Pani, A. (2007). Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial. Journal of Clinical Psychopharmacology, 27,1, 67-70.

    Google Scholar 

  • Neath, I.S. & Surprenant, A.M. (2003). Human Memory. Belmont: Wadsworth/Thomson Learning.

  • O’Shea, E., Escobedo, I., Orio, L., Sanchez, V., Navarro, M., Green, A.R. et al. (2005). Elevation of ambient room temperature has differential effects on mdma-induced 5-ht and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology, 30,7, 1312-1323.

  • Parrott, A.C., Rodgers, J., Buchanan, T., Ling, J., Heffernan, T. & Scholey, A.B. (2006). Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational mdma users. Human Psychopharmacology, 21,5, 285-298.

    Google Scholar 

  • Quednow, B.B., Kuhn, K. ., Hoppe, C., Westheide, J., Maier, W., Daum, I. et al. (2007). Elevated impulsivity and impaired decision-making cognition in heavy users of mdma (‘Ecstasy’). Psychopharmacology (Berlijn), 189,4, 517-530.

  • Raj, V., Liang, H., Woodward, N., Bauernfeind, A., Lee, J., Dietrich, M., Park, S. & Cowan, R. (2009). mdma (ecstasy) use is associated with reduced bold signal change during semantic recognition in abstinent human polydrug users: a preliminary fmri study. Journal of Psychopharmacology, 0, 1-15.

  • Reneman, L., Booij, J., de Bruin, K., Reitsma, J.B., Wolff, F. A. de, Gunning, W. B. et al. (2001a). Effects of dose, sex, and long-term abstention from use on toxic effects of mdma (ecstasy) on brain serotonin neurons. Lancet, 358,9296, 1864-1869.

  • Reneman, L., Win, M.M. de, Brink, W., van den Booij, J. & Heeten, G.J. den (2006). Neuroimaging findings with mdma/ecstasy: technical aspects, conceptual issues and future prospects. Journal of Psychopharmacology, 20,2, 164-175.

  • Roiser, J.P., Rogers, R.D., Cook, L.J. & Sahakian, B.J. (2006). The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls. Psychopharmacology (Berlijn), 188,2, 213-227.

  • Roiser, J.P., Rogers, R.D. & Sahakian, B. . (2007). Neuropsychological function in ecstasy users: a study controlling for polydrug use. Psychopharmacology (Berlijn), 189,4, 505-516.

  • Schilt T., Goudriaan, A.E., Koeter, M.W., Brink, W. van den, & Schmand. B, (2009). Decision making as a predictor of first ecstasy use: a prospective study. Psychopharmacology (Berlijn), 203,3, 519-27.

  • Schilt, T., Win, M.M. de, Jager, G., Korf, D.J., Brink, W. van den et al. (2007). Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study. Archives of General Psychiatry, 64,6, 728-736.

    Google Scholar 

  • Schilt, T., Win, M.M. de, Jager, G., Koeter, M., Ramsey, N.F., Schmand, B., Brink, W. van den, (2008). Specific effects of ecstasy and other illicit drugs on cognition in poly-substance users. Psychological Medicine, 38,09, 1309-1317.

  • Schmitt, J.A., Wingen, M., Ramaekers, J.G., Evers, E.A. & Riedel, W.J. (2006). Serotonin and human cognitive performance. Current Pharmaceutical Design, 12,20, 2473-2486.

    Google Scholar 

  • Soar, K., & Parrott, A. (2004). Persistent neuropsychological problems after 7 years of abstinence from recreational ecstasy (mdma): A case study. Psychological Reports, 95,2, 192-196.

    Google Scholar 

  • Szabo, Z., McCann, U.D., Wilson, A.A., Scheffel, U., Owonikoko, T., Mathews, W. B. et al. (2002). Comparison of (+)-(11)C-McN5652 and (11)c-dasb as serotonin transporter radioligands under various experimental conditions. Journal of Nuclear Medicine, 43,5, 678-692.

    Google Scholar 

  • Terner, J., & Wit, H. de (2006). Menstrual cycle phase and responses to drugs of abuse in humans. Drug and alcohol dependence, 84, 1-13.

    Google Scholar 

  • Thomasius, R., Petersen, K., Buchert, R., Andresen, B., Zapletalova, P., Wartberg, L. et al. (2003). Mood, cognition and serotonin transporter availability in current and former ecstasy (mdma) users. Psychopharmacology (Berlijn), 167,1, 85-96.

    Google Scholar 

  • Thomasius, R., Zapletalova, P., Petersen, K., Buchert, R., Andresen, B., Wartberg, L. et al. (2006). Mood, cognition and serotonin transporter availability in current and former ecstasy (mdma) users: the longitudinal perspective. Journal of Psychopharmacology, 20,2, 211-225.

  • Verdejo-Garcia, A., Lawrence, A.J. & Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. Neuroscience and Biobehavioral Reviews, 32, 777-810.

    Google Scholar 

  • Verheyden, S.L., Henry, J.A. & Curran, H. . (2003). Acute, sub-acute and long-term subjective consequences of ‘ecstasy’ (mdma) consumption in 430 regular users. Human Psychopharmacology, 18,7, 507-517.

  • Wager, T.D., & Smith, E.E. (2003). Neuroimaging studies of working memory: a meta-analysis. Cognitive, Affective and Behavioural Neuroscience, 3,4, 255-274.

    Google Scholar 

  • Wareing, M., Fisk, J.E., Montgomery, C., Murphy, P.N. & Chandler, M.D. (2007). Information processing speed in ecstasy (mdma) users. Human Psychopharmacology, 22,2, 81-88.

    Google Scholar 

  • Wareing, M., Fisk, J.E., Murphy, P. & Montgomery, C. (2004). Verbal working memory deficits in current and previous users of mdma. Human Psychopharmacology, 19,4, 225-234.

    Google Scholar 

  • Wareing, M., Fisk, J.E., Murphy, P., & Montgomery, C. (2005). Visuo-spatial working memory deficits in current and former users of mdma (‘ecstasy’). Human Psychopharmacology, 20,2, 115-123.

  • Win, M.M. de , Jager, G., Vervaeke, H.K., Schilt, T., Reneman, L., Booij, J. et al. (2005). The Netherlands xtc Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance. International Journal of Methods in Psychiatric Research, 14,4, 167-185.

  • Win, M.M. de, Reneman, L., Jager, G., Vlieger, E.J., Olabarriaga, S.D., Lavini, C. et al. (2007). A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users. Neuropsychopharmacology, 32,2, 458-470.

  • Win, M.M. de, Reneman, L., Reitsma, J B., Heeten, G.J. den, Booij, J. & Brink, W. van den (2004). Mood disorders and serotonin transporter density in ecstasy users - the influence of long-term abstention, dose, and gender. Psychopharmacology (Berlijn), 173,3-4, 376-382.

  • Win, M.M. de, Schilt, T., Reneman, L., Vervaeke, H., Jager, G., Dijkink, S., Booij, J. & Brink, W. van den (2006). Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study. Journal of Psychopharmacology, 20,2, 226-35.

  • Zakzanis, K.K., & Young, D.A. (2001). Memory impairment in abstinent mdma (‘Ecstasy’) users: a longitudinal investigation. Neurology, 56,7, 966-969.

    Google Scholar 

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    Jeroen Heijden

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Drs. J.A.R. van der Heijden, psycholoog, Bonairestraat 44 II, 1058 XJ Amsterdam.

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Heijden, J. De langetermijngevolgen van mdma-gebruik op het serotonerge systeem, het werkgeheugen en impulsiviteit. NEPR 13, 124–132 (2009). https://doi.org/10.1007/BF03080165

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