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Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress1

Richard E, van den Heuvel E, Moll van Charante EP, Achthoven L, Vermeulen M, Bindels PJ, van Gool WA

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Nederlands Tijdschrift voor Evidence Based Practice

Samenvatting

De toegenomen levensverwachting hangt samen met een sterke toename van zowel de prevalentie als de incidentie van dementie onder ouderen. Er is voorspeld dat het aantal van 24,3 miljoen patiënten die aan dementie lijden, zich bijna elke 20 jaar verdubbelt tot 81,1 miljoen in het jaar 2040.2 Preventiestrategieën ontbreken vrijwel op dit moment. De ziekte van Alzheimer is de meest voorkomende oorzaak van dementie, gevolgd door vasculaire dementie3, maar het scherpe onderscheid tussen beide vormen lijkt niet langer houdbaar.4 Epidemiologische studies hebben aangetoond dat vasculaire risicofactoren samenhangen met het risico op het krijgen van de ziekte van Alzheimer en cognitief disfunctioneren. 5,6 Daarnaast is het duidelijk geworden dat diabetes mellitus7, hypertensie8,9, hypercholesterolemie10,11, obesitas12,13, roken14 en weinig bewegen15,16 bijdragen aan een verhoogd risico op cognitieve stoornissen en dementie. De rol die vasculaire risicofactoren spelen, roept de vraag op of behandeling en andere interventies het risico op dementie kunnen verlagen.

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Literatuur

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    Berry Middel

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Middel, B. Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress1 . NTEB 7, 9–10 (2009). https://doi.org/10.1007/BF03080114

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