Abstract
Type-1-diabetes is een stofwisselingsziekte die wordt gekenmerkt door een chronisch verhoogde bloedglucosespiegel (hyperglykemie) als gevolg van een insulinesecretiedefect. De behandeling bestaat uit het meermalen daags toedienen van insuline. Ondanks de beschikbaarheid van diverse soorten insuline en moderne toedieningsystemen en technieken om thuis de bloedglucosewaarden te controleren, ervaren patiënten fluctuaties in hun bloedglucosespiegel, variërend van hypoglykemie (lage bloedglucosewaarden) tot hyperglykemie. Langdurige hyperglykemie is verantwoordelijk voor het ontstaan van microvasculaire complicaties, zoals retinopathie, nefropathie en perifere neuropathie. Onbekend is of microvasculaire schade zich ook in het brein manifesteert.
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Mw. dr. A.M. Wessels, neuropsycholoog, vu medisch centrum, Afd. Medische Psychologie, Van der Boechorststraat 7, 1081 BT Amsterdam;
prof. dr. F.J. Snoek, psycholoog, vu medisch centrum Afd. Medische Psychologie;
prof. dr. F. Barkhof, radioloog, vu medisch centrum Afd. Radiologie;
prof. dr. R.J. Heine, internist-diabetoloog, vu medisch centrum, Afd. Endocrinologie.
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Wessels, A., Snoek, F., Barkhof, F. et al. Microvasculaire schade en cognitieve achteruitgang bij type-1-diabetes. NEPR 11, 32–37 (2007). https://doi.org/10.1007/BF03079121
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DOI: https://doi.org/10.1007/BF03079121