Skip to main content
Log in

De ziekte van Huntington: psychologische aspecten van voorspellend testen

  • Artikelen
  • Published:
Neuropraxis

Abstract

De ziekte van Huntington is een autosomaal dominante erfelijke ziekte die wordt gekenmerkt door onwillekeurige bewegingen, cognitieve achteruitgang en psychiatrische problemen. De eerste verschijnselen openbaren zich meestal op middelbare leeftijd.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatuur

  • Adams, P., Falek, A. & Arnold, J. (1988). Huntington disease in Georgia: age at onset, American Journal of Human Genetics, 43, 5, 695-704.

    Google Scholar 

  • American College of Medical Genetics, American Society of Human Genetics & Huntington Disease Genetic Testing Working Group (1998). Laboratory guidelines for Huntington disease genetic testing, American Journal of Human Genetics, 62, 1243-1247.

    Google Scholar 

  • Babul, R., Adam, S., Kremer, B., Dufrasne, S., Wiggins, S., Huggins Marlene, Theilmann, J., Bloch, M. & Hayden, M.R. (1993). Attitudes toward direct predictive testing for the Huntington disease gene. Relevance for other adult-onset disorders., jama, 270, 19, 2321-2325.

  • Bates, G., Harper, P.S. & Jones, L. (2002). Huntington's disease, 3rd edn, Oxford University Press, Oxford.

  • Bijleveld, C.C.J.H., Van der Kamp, L.Th., Mooijaart, A., van der Kloot, W.A., Van der Leeden, R. & Van der Burg, E. (1999). Longitudinal data analysis: designs, models and methods Sage, London.

  • Bloch, M., Fox, S. & Hayden, M.R. (1989). Predictive testing for Huntington disease: II. Demographic characteristics, life-style patterns, attitudes, and psychosocial assessments of the first fifty-one test candidates, American Journal of Medical Genetics, 32, 217-224.

    Google Scholar 

  • Broadstock, M., Michie, S. & Marteau, T.M. (2000). The psychological consequences of predictive genetic testing: a systematic review, European Journal of Human Genetics, 8, 10, 731-738.

    Google Scholar 

  • Bundey, S. (1997). Few psychological consequences of presymptomatic testing for Huntington disease, Lancet, 349, 9044, 4.

    Google Scholar 

  • Burgermeister, J. (2003). Teacher was refused job because relatives have Huntington's disease, British Medical Journal, 327, 827.

    Google Scholar 

  • Burgess, M.M., Adam, S., Bloch, M. & Hayden, M.R. (1997). Dilemmas of anonymous predictive testing for Huntington disease: privacy vs. optimal care, American Journal of Medical Genetics, 71, 197-201.

    Google Scholar 

  • Craufurd, D., Dodge, A., Kerzin-Storrar, L. & Harris, R. (1989). Uptake of presymptomatic predictive testing for Huntington's disease, Lancet, 9, 603-605.

    Google Scholar 

  • Duisterhof, M., Trijsburg, R.W., Niermeijer, M.F., Roos, R.A.C. & Tibben, A. (2001). Psychological studies on Huntington's disease: making up the balance, Journal of Medical Genetics, 38, 852-861.

    Google Scholar 

  • Evers-Kiebooms, G., Cassiman, J.J. & Van den Berghe, H. (1987). Attitudes towards predictive testing in Huntington's disease: a recent survey in Belgium, Journal of Medical Genetics, 24, 275-279.

    Google Scholar 

  • Gutekunst, C.A., Norflus, F. & Hersch, S.M. (2002). The neuropathology of Huntington's disease, 45 edn., 3, G. Bates, P. S. Harper & L. Jones, eds., Oxford University Press, Oxford, 251-275.

  • Harper, P.S., Gevers, S., de Wert, G., Creighton, S., Bombard, Y. & Hayden, M.R. (2004). Genetic testing and Huntington's disease: issues of employment, Lancet Neurology, 3, 4, 249-252.

    Google Scholar 

  • Harper, P.S. & Jones, L. (2002). Huntington's disease: genetic and molecular studies., in Huntington's disease, 3rd edn., G. Bates, P.S. Harper & L. Jones, eds., 113-158.

  • Huntington Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes, Cell, 72, 971-983.

    Google Scholar 

  • Kessler, S., Field, T., Worth, L. & Mosbarger, H. (1987). Attitudes of persons at risk for Huntington disease toward predictive testing, American Journal of Medical Genetics, 26, 259-270.

    Google Scholar 

  • Kremer, B. (2002). Clinical neurology of Huntington's disease ’ Diversity in unity, unity in diversity, 45 edn, 3, G. Bates, P.S. Harper & L. Jones, eds., Oxford University Press, Oxford, 28-61.

  • Kremer, B., Goldberg, P., Andrew, S.E., Theilmann, J., Telenius, H., Zeisler, J., Squitieri, F., Lin, B., Bassett, A., Almqvist, E. et al. (1994). A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring cag repeats, New England Journal of Medicine, 330, 20, 1401-1406.

    Google Scholar 

  • Langbehn, D.R., Brinkman, R.R., Falush, D., Paulsen, J.S., Hayden, M.R. & International Huntington's Disease Collaborative Group (2004). A new model for prediction of the age of onset and penetrance for Huntington's disease based on cag length, Clinical Genetics, 65, 4, 267-277.

    Google Scholar 

  • Maat-Kievit, A., Losekoot, M., Zwinderman, K., Vegter-Van der Vlis, M., Belfroid, R., Lopez, F., Van Ommen, G.-J., Breuning, M.H. & Roos, R.A.C. (2002). Predictability of age at onset in Huntington disease in the Dutch population, Medicine, 81, 4, 251-259.

    Google Scholar 

  • Maat-Kievit, A., Vegter-Van de Vlis, M., Zoeteweij, M., Losekoot, M., Van Haeringen, A. & Roos, R. (2000b). Paradox of a better test for Huntington's disease, J Neurol Neurosur Ps, 69, 5, 579-583.

  • Maat-Kievit, A., Vegter-Van de Vlis, M., Zoeteweij, M., Losekoot, M., Van Haeringen, A. & Roos, R. (2000a). Paradox of a better test for Huntington's disease, J Neurol Neurosur Ps, 69, 5, 579-583.

  • Meiser, B. & Dunn, S. (2000). Psychological impact of genetic testing for Huntington disease: an update of the literature, Journal of Neurology, Neurosurgery and Psychiatry, 69, 5, 574-578.

    Google Scholar 

  • Nance, M.A., Mathias-Hagen, V., Breningstall, G., Wick, M.J. & McGlennen, R.C. (1999). Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease, Neurology, 52, 2, 392-394.

    Google Scholar 

  • Quaid, K.A. & Morris, M. (1993). Reluctance to undergo predictive testing: the case of Huntington disease, American Journal of Medical Genetics, 45, 1, 41-45.

    Google Scholar 

  • Roos, R.A., Vegter-Van der Vlis, M., Van Ommen, G.J.B. & Bruyn, G.W. (1993). Duration of illness in Huntington's disease is not related to age of onset, Journal of Neurology, Neurosurgery and Psychiatry, 56, 98-100.

  • Rubinsztein, D.C., Leggo, J., Coles, R., Almqvist, E., Biancalana, V., Cassiman, J.J., Chotai, K., Connarty, M., Crauford, D., Curtis, A., Curtis, D., Davidson, M.J., Differ, A.M., Dode, C., Dodge, A., Frontali, M., Ranen, N.G., Stine, O.C., Sherr, M., Abbott, M.H., Franz, M.L., Graham, C.A., Harper, P.S., Hedreen, J.C., Hayden, M.R. et al. (1996). Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (hd) gene reveals hd cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats, American Journal of Human Genetics, 59, 1, 16-22.

    Google Scholar 

  • Siegel, S. & Castellan, N.J. Jr. (1988). Nonparametric statistics for the behavioral sciences McGraw-Hill, New York.

  • Siesling, S., Vegter-Van de Vlis, M., Losekoot, M., Belfroid, R.D., Maat-Kievit, J.A., Kremer, H.P. & Roos, R.A. (2000). Family history and dna analysis in patients with suspected Huntington's disease, Journal of Neurology, Neurosurgery and Psychiatry, 69, 1, 54-59.

  • Teltscher, B. & Polgar, S. (1981). Objective knowledge about Huntington's disease and attitudes towards predictive tests of persons at risk, Journal of Medical Genetics, 18, 31-39.

    Google Scholar 

  • The World Federation of Neurology Research Group on Huntington's Disease (1993). Presymptomatic testing for Huntington's disease: a world survey, Journal of Medical Genetics, 30, 1020-1022.

    Google Scholar 

  • Tibben, A., Timman, R., Bannink, E.C. & Duivenvoorden, H.J. (1997). Three year follow up after presymptomatic testing for Huntington's disease in tested individuals and partners, Health Psychology, 16, 1, 20-35.

    Google Scholar 

  • Timman, R., Roos, R.A.C., Maat-Kievit, A. & Tibben, A. (2004). Adverse effects of predictive testing for Huntington disease underestimated: long term effects 7-10 years after the test., Health Psychology, 23, 2, 189-197.

    Google Scholar 

  • Timman, R., Maat-Kievit, A., Brouwer-DudokdeWit, C., Zoeteweij, M., Breuning, M.H. & Tibben, A. (2003). Testing the test ’ why pursue a better test for Huntington disease?, American Journal of Medical Genetics, 117B, 79-85.

  • Timman, R., Stijnen, T. & Tibben, A. (2004). Methodology in longitudinal studies on psychological effects of predictive dna-testing: A review, Journal of Medical Genetics, 41, 7, e100.

    Google Scholar 

  • Tyler, A., Ball, D. & Craufurd, D. (1992). Presymptomatic testing for Huntington's disease in the United Kingdom, British Medical Journal, 304, 11593-1596.

    Google Scholar 

  • Van Der Steenstraten, I.M., Tibben, A., Roos, R.A.C., Van Der Kamp, J.J.P. & Niermeijer, M.F. (1994). Predictive testing for Huntington disease: nonparticipants compared with participants in the Dutch program, American Journal of Human Genetics, 55, 618-625.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reinier Timman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Timman, R. De ziekte van Huntington: psychologische aspecten van voorspellend testen. NEPR 9, 74–79 (2005). https://doi.org/10.1007/BF03079044

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03079044

Navigation