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Cognitie, connectiviteit en hemisferische lateraliteit: onderzoek bij gezonde ouderen en patiënten met de ziekte van Alzheimer

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Neuropraxis

Abstract

Bij de ziekte van Alzheimer zijn verschillende cognitieve functies aangedaan, waaronder geheugen, aandacht en taalfuncties. Alhoewel in veel minder ernstige vorm, is ook bij gezonde veroudering een achteruitgang in deze functies te zien. Cognitieve functies berusten op geïntegreerde activiteit van neurale systemen binnen de hersenen. Om informatie uit te kunnen wisselen moeten hersengebieden met elkaar verbonden zijn en hierbij speelt de witte stof een belangrijke rol.

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Literatuur

  • Barkhof, F.J., Elton, M., Lindeboom, J., Tas, M. W., Schmidt, W.F., Hommes, O.R. et al. (1998). Functional correlates of callosal atrophy in relapsing-remitting multiple sclerosis patients. A preliminary mri study. J Neurol 245, 153-158.

    Google Scholar 

  • Bartzokis, G., Sultzer, D., Lu, P.H., Nuechterlein, K.H., Mintz, J., Cummings, J.L. (2004). Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical ‘disconnection’ in aging and Alzheimer's disease. Neurobiol Aging. 25, 843-51.

    Google Scholar 

  • Black, S.E., Moffat, S.D., Yu, D.C., Parker, J., Stanchev, P. & Bronskill, M. (2000). Callosal atrophy correlates with temporal lobe volume and mental status in Alzheimer's disease. Can J Neurol Sci, 27, 204-209.

    Google Scholar 

  • Bokde, A.L., Teipel, S.J., Zebuhr, Y., Leinsinger, G., Gootjes, L., Schwarz, R. et al. (2002). A new rapid landmark-based regional MRI segmentation method of the brain. J Neurol Sci, 194, 35-40.

    Google Scholar 

  • Bouma, A. (1996). Dichotische luistertaak. In A. Bouma, J.Mulder & J. Lindeboom, (eds). Neuropsychologische diagnostiek: handboek. Lisse: Swets & Zeitlinger; 1996.

  • DeCarli, C., Murphy, D.G., Tranh, M., Grady, C.L., Haxby, J.V., Gillette, J.A. et al. (1995). The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology, 45, 2077-2084.

  • Dik, M.G., Jonker, C., Comijs, H.C., Bouter, L.M., Twisk, J.W., van Kamp, G.J. et al. (2001). Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly. Neurology, 57, 2217-2222.

    Google Scholar 

  • Gadea, M., Marti-Bonmati, L., Arana, E., Espert, R., Casanova, V. & Pascual, A. (2002). Dichotic listening and corpus callosum magnetic resonance imaging in relapsing-remitting multiple sclerosis with emphasis on sex differences. Neuropsychology, 16, 275-281.

    Google Scholar 

  • Gazzaniga, M.S. (2000). Cerebral specialization and interhemispheric communication: does the corpus callosum enable the human condition? Brain, 123 (Pt 7), 1293-1326.

    Google Scholar 

  • Gootjes, L (2004a). Hemispheric connectivity and laterality of language processing: exploring the brain of young adults, elderly, and Alzheimer patients. Unpublished PhD thesis, Vrije Universiteit, Amsterdam, the Netherlands.

  • Gootjes, L., Teipel, S.J., Zebuhr, Y., Schwarz, R., Leinsinger, G., Scheltens, Ph. et al. (2004b). Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging. Dementia and Geriatric Cognitive disorders 18, 2, 180-188 (Epub 2004, June 21).

  • Hensel, A., Wolf, H., Kruggel, F., Riedel-Heller, S.G., Nikolaus, C., Arendt, T. et al. (2002). Morphometry of the corpus callosum in patients with questionable and mild dementia. J Neurol Neurosurg Psychiatry, 73, 59-61.

    Google Scholar 

  • Hugdahl, K. (2003). Dichotic listening in the study of auditory laterality. In K. Hugdahl & R.J. Davidson (eds.), The asymmetrical brain (pp. 441-475). Cambridge, Massachusetts: The MIT Press.

  • Janowsky, J.S., Kaye, J.A. & Carper, R.A. (1996). Atrophy of the corpus callosum in Alzheimer's disease versus healthy aging. J Am Geriatr Soc., 44, 798-803.

    Google Scholar 

  • Kang, E., Lee, D.S., Lee, J.S., Kang, H., Hwang, C.H., Oh, S.H. et al. (2003). Developmental hemispheric asymmetry of interregional metabolic correlation of the auditory cortex in deaf subjects. Neuroimage, 19, 777-783.

    Google Scholar 

  • Kimura, D. (1967). Functional asymmetry of the brain in dichotic listening. Cortex, 3, 163-178.

    Google Scholar 

  • Meier-Ruge, W., Ulrich, J., Bruhlmann, M. & Meier, E. (1992). Age-related white matter atrophy in the human brain. Ann N Y Acad Sci, 673, 260-269.

    Google Scholar 

  • Peled, S., Gudbjartsson, H., Westin, C.F., Kikinis, R. & Jolesz, F.A. (1998). Magnetic resonance imaging shows orientation and asymmetry of white matter fiber tracts. Brain Res, 780, 27-33.

    Google Scholar 

  • Pollmann, S., Maertens, M., Von Cramon, D.Y., Lepsien, J. & Hugdahl, K. (2002). Dichotic listening in patients with splenial and nonsplenial callosal lesions. Neuropsychology, 16, 56-64.

  • Semmes, J. (1968). Hemispheric Specialization ’ A Possible Clue to Mechanism. Neuropsychologia, 6, 11-26.

  • Scheltens, P., Barkhof, F., Leys, D., Wolters, E.C., Ravid, R. & Kamphorst, W. (1995). Histopathologic correlates of white matter changes on mri in Alzheimer's disease and normal aging. Neurology, 45, 883-888.

    Google Scholar 

  • Stam, C.J. & van Dijk, B.W. (2002). Synchronization likelihood: an unbiased measure of generalized synchronization in multivariate data sets. Physica D, 163, 236-251.

    Google Scholar 

  • Swanberg, M.M., Tractenberg, R.E., Mohs, R., Thal, L.J., Cummings, J.L. (2004). Executive dysfunction in Alzheimer disease. Arch Neurol, 61, 556-60.

    Google Scholar 

  • Varela, F., Lachaux, J.P., Rodriguez, E. & Martinerie, J. (2001). The brainweb: Phase synchronization and large-scale integration. Nat Rev Neurosci, 2, 229-239.

    Google Scholar 

  • Yamauchi, H., Fukuyama, H. & Shio, H. (2000). Corpus callosum atrophy in patients with leukoaraiosis may indicate global cognitive impairment. Stroke, 31, 1515-20.

    Google Scholar 

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Correspondence to Liselotte Gootjes.

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Gootjes, L. Cognitie, connectiviteit en hemisferische lateraliteit: onderzoek bij gezonde ouderen en patiënten met de ziekte van Alzheimer. NEPR 9, 70–73 (2005). https://doi.org/10.1007/BF03079043

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