Skip to main content
Log in

Verkleving van de labia minora

  • Artikelen
  • Published:
Tijdschrift voor Kindergeneeskunde

Samenvatting

Verkleving van de kleine schaamlippen (labia minora) komt vaak voor bij prepuberale meisjes met name tussen de 13 en 23 maanden. De labia minora zijn mediaan met elkaar gefuseerd. Meestal blijft de verkleving asymptomatisch en in 80% van de gevallen verdwijnt de verkleving spontaan binnen een jaar. De verkleving kan leiden tot stasis van urine waardoor een bacteriurie kan optreden. De meest voorkomende klachten van labiaverklevingen zijn urineweginfecties, vaginale pijn of jeuk en urineretentie. De oorzaak van de verkleving is waarschijnlijk multifactorieel waarbij hypo-oestrogeniteit een belangrijke rol speelt. De meest gebruikte therapie is oestrogeenhoudende zalf. Deze crème moet een- tot tweemaal daags gedurende enkele weken op de verkleving worden aangebracht. Het succespercentage van deze behandeling ligt tussen de 50 en 100%. Een andere optie met vergelijkbaar succes is betamethasoncrème. Alleen in uitzonderlijke gevallen is operatief klieven geïndiceerd.

Summary

Labial adhesions appear frequently in prepubertal girls. It is most common in girls aged 13 till 23 months. The labia minora are fused in the midline. Most girls are asymptomatic and in 80% the adhesions disappear within one year. The adhesion can lead to stasis of urine which in turn can lead to bacteruria. Urinary tract infections, vaginal pain or itching and acute urine retention can be the presenting complaint. The cause of labial adhesions is not completely known but the low estrogen levels are most likely involved. The most used treatment is topical estrogen. This is used once or twice daily for several weeks. The success rate ranges from 50 to 100%. Another option is bethamethasone cream with similar success rates. The operative treatment (cleavage of adhesion) is only indicated in exceptional cases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatuur

  1. Dewees WP. Of adhesion of the labia pudendi of children. In: Dewees WP. A treatise on the physical and medical treatment of children. Londen: Miller, 1826. p 384-6.

  2. Schober J, Dulabon L, Martin-Alguacil N, et al. Significance of topical estrogens to labial fusion and vaginal introital integrity. J Pediatr Adolesc Gynecol. 2006;19:337-9.

    Google Scholar 

  3. Leung AK, Robson WL, Tay-Uyboco J. The incidence of labial fusion in children. J Paediatr Child Health. 1993;29:235-6.

    Google Scholar 

  4. Leung AK, Robson WL, Kao CP, et al. Treatment of labial fusion with topical estrogen therapy. Clin Pediatr (Phila). 2005;44:245-7.

    Google Scholar 

  5. Bacon JL. Prepubertal labial adhesions: evaluation of a referral population. Am J Obstet Gynecol. 2002;187:327-31.

    Google Scholar 

  6. Myers JB, Sorensen CM, Wisner BP, et al. Betamethasone cream for the treatment of pre-pubertal labial adhesions. J Pediatr Adolesc Gynecol. 2006;19:407-11.

    Google Scholar 

  7. Lubsen-Brandsma MA. Adhesies van de labia minora bij 3 jonge meisjes. Ned Tijdschr Geneeskd. 2003;147:53-6.

    Google Scholar 

  8. Nurzia MJ, Eickhorst KM, Ankem MK, et al. The surgical treatment of labial adhesions in pre-pubertal girls. J Pediatr Adolesc Gynecol. 2003;16:21-3.

    Google Scholar 

  9. Heger AH, Ticson L, Guerra L, et al. Appearance of the genitalia in girls selected for nonabuse: review of hymenal morphology and nonspecific findings. J Pediatr Adolesc Gynecol. 2002:15:27-35.

    Google Scholar 

  10. McCann J, Wells R, Simon M, et al. Genital findings in prepubertal girls selected for nonabuse: a descriptive study. Pediatrics. 1990;86:428-39.

    Google Scholar 

  11. Leung AK, Robson WL. Labial fusion and urinary tract infection. Child Nephrol Urol. 1992;12:62-4.

    Google Scholar 

  12. Leung AK, Robson WLM. Labial fusion and asymptomatic bacteriuria. Eur J Pediatr. 1993;152: 250-1.

    Google Scholar 

  13. Norbeck JC, Ritchey MR, Bloom DA. Labial fusion causing upper urinar tract obstruction. Urology. 1993;42:209-11.

    Google Scholar 

  14. Pokorny SF. Prepubertal vulvovagonipathies. Obstet Gynecol Clin North Am. 1992;19:39-58.

  15. Omar HA. Management of labial adhesions in prepubertal girls. J Pediatr Adolesc Gynecol. 2000;13:183-5.

    Google Scholar 

  16. Muram D. Treatment of prepubertal girls with labial adhesions. J Pediatr Adolesc Gynecol. 1999;12: 67-70.

    Google Scholar 

  17. Kumetz LM, Quint EH, Fisseha S, Smith YR. Estrogen treatment success in recurrent and persistent labial agglutination. J Pediatr Adolesc Gynecol. 2006;19:381-4.

    Google Scholar 

  18. Tebruegge M, Misra I, Nerminathan V. Is the topical application of oestrogen cream an effective intervention in girls suffering from labial adhesions? Arch Dis Child. 2007;92:268-71.

    Google Scholar 

  19. Smith C, Smith DP. Office pediatric urologic procedures from a parental perspective. Urology. 2000;55:272-6.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. P. de Winter.

Additional information

Mw. drs. J.A. Terwisscha van Scheltinga, coassistent kindergeneeskunde, mw. dr. J.A.E. van Wijk, kinderarts-nefroloog, VU medisch centrum, Amsterdam. Dhr. dr. J.P. de Winter, kinderarts, Spaarne Ziekenhuis, Hoofddorp.

Correspondentieadres: Dr. J.P. de Winter, Spaarne Ziekenhuis, Postbus 770, 2130 AT Hoofddorp,

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Winter, J.P., van Scheltinga, J.A.T. & van Wijk, J.A.E. Verkleving van de labia minora. KIND 76, 238–241 (2008). https://doi.org/10.1007/BF03078211

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03078211

Navigation