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Neuroanatomie van de dwangstoornis

Samenvatting

De obsessieve compulsieve stoornis (ocs; in het Engels ‘obsessive-compulsive disorder’, afgekort tot ocd en in het Nederlands ook wel dwangstoornis genoemd) is een veelvoorkomende en chronische neuropsychiatrische stoornis die gekenmerkt wordt door obsessies (dwanggedachten) en compulsies (dwanghandelingen). Obsessies zijn steeds terugkerende intrusieve gedachten of beelden die als opdringend en niet-eigen beleefd worden. Ze veroorzaken angst of spanning. Als reactie op dit ongemak worden ter neutralisatie compulsies uitgevoerd. Compulsies zijn repetitieve gedragingen zoals controlehandelingen of mentale activiteiten zoals het opzeggen van goede gedachten. Deze kennen vaak een ritueel karakter of moeten uitgevoerd worden volgens strikte regels. De diagnose ocs wordt vastgesteld als de klachten meer dan één uur per dag bestaan en significant interfereren met het dagelijkse leven.

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Literatuur

  1. Abelson, J.L., Curtis, G.C., Sagher, O., Albucher, R.C., Harrigan, M., Taylor, S.F., Martis, B. & Giordani, B. (2005). Deep brain stimulation for refractory obsessive-compulsive disorder. Biological Psychiatry, 57, 510–6.

    Google Scholar 

  2. Alexander, G.E., DeLong, M.R. & Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of.Neuroscience, 9, 357–381.

    Google Scholar 

  3. An, S.K., Mataix-Cols, D., Lawrence, N.S., Wooderson, S., Giampietro, V., Speckens, A., Brammer, M.J. & Phillips, M.L. (in druk). To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder. Molecular Psychiatry.

  4. Aouizerate, B., Guehl, D., Cuny, E., Rougier, A., Bioulac, B., Tignol, J. & Burbaud, P. (2004). Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Progress in Neurobiology, 72, 195–221.

    Google Scholar 

  5. Carmona, S., Bassas, N., Rovira, M., Gispert, J.D., Soliva, J.C., Prado, M. Tomas, J. Bulbena, A. & Vilarroya, O. (2007). Pediatric ocd structural brain deficits in conflict monitoring circuits: a voxel-based morphometry study. Neuroscience Letters, 29,421, 218–23.

    Google Scholar 

  6. Cavedini, P., Riboldi, G., D'Annucci, A., Belotti, P., Cisima, M. & Bellodi, L. (2002). Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia, 40, 205–11.

    Google Scholar 

  7. Chamberlain, S.R., Blackwell, A.D., Fineberg, N.A., Robbins, T.W. & Sahakian, B.J. (2005). The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience and Biobehavioral Reviews, 29, 399–419.

    Google Scholar 

  8. Chamberlain, S.R., Fineberg, N.A., Menzies, L.A., Blackwell, A.D., Bullmore, E.T., Robbins, T.W. & Sahakian, B.J. (2007a). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. American Journal of Psychiatry, 164, 335–338.

    Google Scholar 

  9. Chamberlain, S.R., Fineberg, N.A., Blackwell, A.D., Clark, L., Robbins, T.W. & Sahakian, B.J.. (2007b). A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania. Neuropsychologia, 45, 654–662.

  10. Goudriaan, A.E., Oosterlaan, J., Beurs, E. de & Brink, W. van den (2006). Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101, 534–47.

    Google Scholar 

  11. Gehring, W.J., Himle, J. & Nisenson, L.G. (2000). Action-monitoring dysfunction in obsessive-compulsive disorder. Psychological Science, 11, 1–6.

    Google Scholar 

  12. Hester, R. & Garavan, H. (2004). Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. The Journal of Neuroscience, 24, 11017–11022.

    Google Scholar 

  13. Heuvel, O.A. van den, Groenewegen, H.J., Barkhof, F., Lazeron, R.H., Van, D.R. & Veltman, D.J. (2003). Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task. Neuroimage, 18, 367–374.

  14. Heuvel, O.A. van den, Remijnse, P.L., Mataix-Cols, D., Vrenken, H., Groenewegen, H.J., Uylings, H.B.M., van Balkom, A.J.L.M., Veltman. D.J. (aangeboden). The major symptom dimensions of ocd are mediated by partially distinct neural systems: a voxel-based morphometry study of 55 unmedicated patients.

  15. Heuvel, O.A. van den, Veltman, D.J., Groenewegen, H.J., Dolan, R.J., Cath, D.C., Boellaard, R., Mesina, C.T., Balkom, A.J. van, Oppen, P. van, Witter, M.P., Lammertsma, A.A. & Dyck, R. van. (2004). Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography. Psychiatry Research, 132, 225–237.

    Google Scholar 

  16. Heuvel, O.A. van den, Veltman, D.J., Groenewegen, H.J., Witter, M.P., Merkelbach, J., Cath, D.C., Balkom, A.J. van, Oppen, P. van, Dyck, R. van. (2005a). Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Archives of General Psychiatry, 62, 922–33.

  17. Heuvel, O.A. van den, Veltman, D.J., Groenewegen, H.J., Barkhof, F., Lazeron, R.H., Dyck van, R. & Veltman, D.J. (2005b). Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Archives of General Psychiatry, 62, 301–309.

    Google Scholar 

  18. Hollander, E., Kim, S., Khanna, S. & Pallanti, S. (2007). Obsessive-compulsive disorder and obsessive-compulsive spectrum disorders: diagnostic and dimensional issues. CNS Spectrums, 12,(2 Suppl 3), 5–13.

    Google Scholar 

  19. Kim, J.J., Lee, M.C., Kim, J., Kim, I.Y., Kim, S.I., Hee Han, M., Chang, K.-H. & Kwon, J. S. (2001). Grey matter abnormalities in obsessive-compulsive disorder – Statistical parametric mapping of segmented magnetic resonance images. British Journal of Psychiatry, 179, 330–4.

    Google Scholar 

  20. Lawrence, N.S., An, S.K., Mataix-Cols, D., Ruths, F., Speckens, A. & Phillips, M.L. (2007). Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in ocd. Biological Psychiatry, 61, 1072–1080.

    Google Scholar 

  21. Leckman, J.F., Grice, D.E., Boardman, J., Zhang, H., Vitale, A., Bondi, C., Alsobrook, J., Peterson, B.S., Cohen, J.D., Rasmussen, S.A., Goodman, W.K., McDougle, C.J. & Pauls, D.L.(1997). Symptoms of obsessive-compulsive disorder. American Journal of Psychiatry, 154, 911–917.

  22. Leckman, J.F., Rauch, S.L., Mataix-Cols, D. (2007). Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-V. CNS Spectrums, 12, 376–400.

    Google Scholar 

  23. Maltby, N., Tolin, D.F., Worhunsky, P., O’Keefe, T.M. & Kiehl, K.A. (2005). Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fmri study. Neuroimage, 24, 495–503.

    Google Scholar 

  24. Mataix-Cols, D., Wooderson, S., Lawrence, N., Brammer, M.J., Speckens, A. & Phillips, M.L. (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Archives of General Psychiatr, 61, 564–76.

    Google Scholar 

  25. Mataix-Cols, D., do Rosario-Campos, M.C., Leckman, J.F. (2005). A multidimensional model of obsessive-compulsive disorder. American Journal of Psychiatry, 162, 228–38.

    Google Scholar 

  26. Mataix-Cols, D. & Heuvel, O.A. van den. (2006). Common and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatric Clinics of North America, 29, 391–410.

    Google Scholar 

  27. McGuire, P.K., Bench, C.J., Frith, C.D., Marks, I.M., Frackowiak, R.S. & Dolan, R.J. (1994). Functional anatomy of obsessive-compulsive phenomena. British Journal of Psychiatry, 164, 459–468.

    Google Scholar 

  28. Menzies, L., Achard, S., Chamberlain, S.R., Fineberg, N., Chen, C.H., del Campo, N., Sahakian, B.J., Robbins, T.W. & Bullmore, E. (2007). Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain, 130, 3223–3236.

    Google Scholar 

  29. Muller, S.V., Johannes, S., Wieringa, B., Weber, A., Müller-Vahl., K., Matzke, M., Kolbe, H., Dengler, R. & Münte, T.F. (2003). Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder. Behavioral Neurology, 14, 29–37.

    Google Scholar 

  30. Nielen, M.M., Veltman, D.J., De, J.R., Mulder, G. & Boer, J.A. den. (2002). Decision making performance in obsessive compulsive disorder. Journal of Affective Disorders, 69, 257–260.

    Google Scholar 

  31. Pujol, J., Soriano-Mas, C., Alonso, P., Cardoner, N., Menchón, J.M., Deus, J. & Vallejo, J. (2004). Mapping structural brain alterations in obsessive-compulsive disorder. Archives of General Psychiatry, 61, 720–30

    Google Scholar 

  32. Rauch, S.L., Jenike, M.A., Alpert, N.M., Baer, L., Breiter, H.C., Savage, C.R. & Fischman, A.J. (1994). Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Archives of General Psychiatry, 51, 62–70.

    Google Scholar 

  33. Remijnse, P.L., Heuvel, O.A. van den & Veltman, D,J,. (2005). Neuroimaging in obsessive-compulsive disorder. Current Medical Imaging Reviews, 1, 331–351.

  34. Remijnse, P.L., Nielen, M.M., Balkom, A.J. van, Cath, D.C., Oppen, P.van, Uylings, H.B. & Veltman, D.J. (2006). Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Archives of General Psychiatry, 63, 1225–1236.

    Google Scholar 

  35. Rolls, E.T. (1999). The functions of the orbitofrontal cortex. Neurocase, 5, 301–312.

    Google Scholar 

  36. Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H,S,, West, J.D. & Mamourian, A.C. (2007). Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biological Psychiatry, 62, 901–909.

  37. Rubia, K., Smith, A.B., Brammer, M.J., Toone, B. & Taylor, E. (2005). Abnormal brain activation during inhibition and error detection in medication-naive adolescents with adhd. American Journal of Psychiatry, 162, 1067–1075.

    Google Scholar 

  38. Saxena, S,, Brody, A.L., Schwartz, J.M. & Baxter, L.R. (1998). Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. British Journal of Psychiatry, 173, 26–37.

    Google Scholar 

  39. Saxena, S., Brody, A.L., Maidment, K.M., Smith, E.C., Zohrabi, N., Katz, E., Baker, S.K. & Baxter, L.R., Jr. (2004). Cerebral glucose metabolism in obsessive-compulsive hoarding. American Journal of Psychiatry, 161, 103810–48.

    Google Scholar 

  40. Smith, A.B., Taylor, E., Brammer, M., Toone, B. & Rubia, K. (2006). Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. American Journal of Psychiatry, 163, 104410–51.

    Google Scholar 

  41. Ursu, S., Stenger, V.A., Shear, M.K., Jones, M.R. & Carter, C.S. (2003). Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychological Science, 14, 347–353.

    Google Scholar 

  42. Valente, A.A., Miguel, E.C., Castro, C.C., Amaro, E., Jr., Duran, F.L., Buchpiguel, C.A., Chitnis, X., McGuire, P.K. & Busatto, G.F. (2005). Regional grey matter abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study. Biological Psychiatry, 58, 479–487.

    Google Scholar 

  43. Wee, N.J. van der, Ramsey, N.F., Jansma, J.M., Megen, H.J. van, Denys, D., Westenberg, H.G. & Kahn, R.S. (2003). Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. Neuroimage, 20, 2271–2280.

    Google Scholar 

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Correspondence to Odile van den Heuvel.

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Mw. dr. O.A. van den Heuvel, psychiater, Afdeling Psychiatrie, vu Medisch Centrum p/a Psychiatrisch Consultatieve Dienst (pcd), vumc, Postbus 7057, 1007 MB, Amsterdam en Afdeling Anatomie & Neurowetenschappen, vumc, Amsterdam,

drs. P.L. Remijnse, psychiater in opleiding, Afdeling psychiatrie, vu Medisch Centrum (vumc), Amsterdam en Stichting Buitenamstel Geestgronden (sbg), Amsterdam

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van den Heuvel, O., Remijnse, P. Neuroanatomie van de dwangstoornis. NEPR 12, 77–85 (2008). https://doi.org/10.1007/BF03077124

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