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Lichte Cognitieve Stoornissen (MCI): Prodromen van dementie?

Abstract

Mild cognitive impairment: a prodromal phase of dementia? Cognitive decline without dementia is common among older persons. A variety of clinical concepts have been introduced in the past 30 years, in order to describe these cognitive deficits arising in older persons. The most frequently used concept is Mild Cognitive Impairment (MCI). MCI is generally seen as a prodromal phase of Alzheimer disease (AD). Several concepts are described, with the neuropsychiatric features and predictors of conversion to dementia c.q. AD. Finally, consequences of preclinically diagnoses for health care are clarified.

Tijdschr Gerontol Geriatr 2007; 38:115-121

Samenvatting

Cognitieve beperkingen zónder dat er sprake is van dementie komen bij ouderen frequent voor. Er zijn om deze cognitieve beperkingen te kunnen definiëren, de afgelopen 30 jaar meerdere klinische concepten in het leven geroepen. Het meest gebruikte en onderzochte concept is MCI (mild cognitive impairment). MCI wordt in het algemeen als het voorstadium van de ziekte van Alzheimer gezien. De verschillende concepten worden besproken, waarbij tevens aandacht besteed zal worden aan begeleidende neuropsychiatrische verschijnselen en predictoren die de kans op conversie naar dementie i.c. de ziekte van Alzheimer verhogen. Tot slot worden de beleidsconsequenties van preklinische diagnostiek van dementie besproken.

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Literatuur

  • Petersen RC, Smith GE, Warung SC e.a. Mild cognitive impairment. Clinical characterization and outcome. Arch Neurol 1999; 56:303-308.

    Article  CAS  PubMed  Google Scholar 

  • Unverzagt FW, Gao S, Baiyewu O e.a. Prevalence of cognitive impairment. Data from the Indianapolis Study of Health and Aging. Neurology 2001; 57: 1655-1662

    CAS  PubMed  Google Scholar 

  • Lopez OL, Jagust WJ, DeKosky ST e.a. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study (CHS): Cognition Study. Arch Neurol 2003a; 60:1385-1389

    Article  Google Scholar 

  • Dik MG. Cognitive decline in older persons. Contribution of genetics, health and lifestyle. Thesis, VU Medisch Centrum 2002, Amsterdam

    Google Scholar 

  • Lopez OL, Jagust WJ, Dulberg C e.a. Riskfactors for mild cognitive impairment in the cardiovascular Health Study (CHS): Cognition Study. Arch Neurol 2003b; 60:1394-1399

    Article  Google Scholar 

  • Kral VA. Senescent forgetfulness: benign and malignant. J Can Med Assoc 1962; 86:257-260

    CAS  Google Scholar 

  • Crook T, Bartus RT, Ferris SH e.a. Age associated memory impairment: proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health Work Group. Developmental Neuropsychology 1986; 2:261-276

    Article  Google Scholar 

  • Levy R. Aging-associated cognitive decline. Int Psychogeriatrics 1994; 6:63-68

    Article  CAS  Google Scholar 

  • Richards M, Touchon J, Ledésert B e.a. Cognitive decline in ageing: are AAMI and AACD distinct entities? Int J Geriatr Psychiatry 1999; 14:534-540

    Article  CAS  PubMed  Google Scholar 

  • Graham JE, Rockwood K, B Lynn Beattie e.a. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 1997; 349:1793-1796

    Article  CAS  PubMed  Google Scholar 

  • Rubin EH, Kinscherf D. Psychopathology of very mild dementia of the Alzheimertype. Am J Psychiatry 1989; 146:1017-1021

    CAS  PubMed  Google Scholar 

  • Zaudig M A. new systematic method of measurement and diagnosis of "mild cognitive impairment" and dementia according to ICD-10 and DSM-IIIR criteria. Int Psychogeriatr 1992; suppl 2:203-219.

    Google Scholar 

  • Petersen RC, Doody R, Kurz A e.a. Current concepts in Mild Cognitive Impairment. Arch Neurol 2001; 58:1985-1992.

    Article  CAS  PubMed  Google Scholar 

  • Petersen RC. Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine 2004; 256:183-194

    Article  CAS  PubMed  Google Scholar 

  • Visser PJ, Scheltens P, Verhey FRJ. Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer’s disease? J Neurol Neurosurg Psychiatry 2005; 76:1348-1354

    Article  CAS  PubMed  Google Scholar 

  • Schmand B, Jonker C, Hooijer C e.a. Subjective memory complaints may announce dementia. Neurology 1996; 46:121-125.

    CAS  PubMed  Google Scholar 

  • Bowen J, Teri L, Kukull W e.a. Progression to dementia in patients with isolated memory loss. Lancet 1997; 349:763-765

    Article  CAS  PubMed  Google Scholar 

  • Hodges J. The amnestic prodrome of Alzheimer's disease. Brain 1998; 121:1601-1602

    Article  PubMed  Google Scholar 

  • Ritchie K & Touchon J. Mild cognitive impairment: conceptual basis and current nosological status. Lancet 2000; 355:225-228

    Article  CAS  PubMed  Google Scholar 

  • Daly E, Zaitchik D, Copeland M e.a. Predicting conversion to Alzheimer disease using standardized clinical information. Arch Neurol 2000; 57:675-680

    Article  CAS  PubMed  Google Scholar 

  • Chen P, Ratcliff D, Belle SH e.a. Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented. Neurology 2000; 55:1847-1853

    CAS  PubMed  Google Scholar 

  • Wang QS & Zhou JN. Retrieval and encoding of episodic memory in normal aging and patients with mild cognitive impairment. Brain Research 2002; 924:113-115

    Article  CAS  PubMed  Google Scholar 

  • Berg L, Hughes CP, Danziger WL e.a. Mild senile dementia of Alzheimertype (SDAT): research diagnostic criteria, recruitment, and description of a study population. J Neurol Neurosurg Psychiatr 1982; 45:962-968

    Article  CAS  PubMed  Google Scholar 

  • Ritchie K Artero S, Touchon J. Classification criteria for mild cognitive impairment. A population-based validation study. Neurology 2001; 56:37-42

    CAS  PubMed  Google Scholar 

  • McKelvey R, Bergman H, Stern J. Lack of prognostic significance of SPECT abnormalities in elderly subjects with a mild memory loss. Can J Neurol 1999; Sci 26:23-28

    CAS  Google Scholar 

  • Bennett DA, Wilson RS, Schneider JA. e.a. Natural history of mild cognitive impairment in older persons. Neurology 2002; 59:198-205

    CAS  PubMed  Google Scholar 

  • Morris JC, Storandt M, Miller JP e.a. Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001; 58:397-405

    Article  CAS  PubMed  Google Scholar 

  • Tabert MH, Albert SM, Borukhova-Milov L e.a. Functional deficits in patients with mild cognitive impairment. Neurology 2002; 58:758-764

    CAS  PubMed  Google Scholar 

  • Larrieu S, Letteneur L, Orgogozo JM. e.a. Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology 2002; 59:1594-1599

    CAS  PubMed  Google Scholar 

  • Fisk JD, Merry HR, Rockwood K. Variations in case definition affect prevalence but not outcomes of mild cognitive impairment. Neurology 2003; 61:1179-1184

    PubMed  Google Scholar 

  • Ganguli M, Dodge HH, Shen C e.a. Mild cognitive impairment, amnestic type. An epidemiologic study. Neurology 2004; 63:115-121

    PubMed  Google Scholar 

  • Comijs HC, Dik MG, Deeg DJH, e.a. The course of cognitive decline in older persons: results from the Longitudinal Aging Study Amsterdam. Dement Geriatr Cogn Disord 2004; 17:136-142

    Article  PubMed  Google Scholar 

  • Petry S, Cummings JL, Hill MA e.a. Personality alterations in dementia of the Alzheimer type. A three-year follow-up study. J Geriatr Psychiatry Neurology 1989; 2:203-207

    Article  CAS  Google Scholar 

  • Cummings JL, Mega M, Gray K e.a. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-2314

    CAS  PubMed  Google Scholar 

  • Lyketsos CG, Lopez O, Jones B e.a. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. JAMA 2002; 288:1475-1483.

    Article  PubMed  Google Scholar 

  • Hwang TJ, Masterman DL, Ortiz F e.a. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alz Dis Assoc Disord 2004; 18 :17-21

    Article  Google Scholar 

  • Feldman H, Scheltens P, Scarpini E e.a. Behavioral symptoms in mild cognitive impairment. Neurology 2004; 62:1199-1201

    CAS  PubMed  Google Scholar 

  • Geerlings MI, Schoevers RA, Beekman ATF e.a. Depression and the risk of cognitive decline and Alzheimer's disease. Br J Psychiat 2000; 176, 568-575.

    Article  CAS  Google Scholar 

  • Ready RE, Ott BR, Grace J. Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry 2003; 11:222-228

    PubMed  Google Scholar 

  • Modrego PJ, Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type. A prospective cohort study. Arch Neurol 2004; 61:1290-1293

    Article  PubMed  Google Scholar 

  • Tierney MC, Boyle E, Lam E. e.a. Do depressive symptoms in memory-impaired elders predict probable Alzheimer’s disease? Aging & Mental Health 1999; 3:88-93

    Article  Google Scholar 

  • Jack CR, Petersen RC, Xu YC e.a. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999; 52:1397-1403

    PubMed  Google Scholar 

  • Blennow K & Hampel H. CSF markers for incipient Alzheimer’s disease. Lancet Neurol 2003; 2:605-613

    Article  CAS  PubMed  Google Scholar 

  • Arai H, Nakagawa T, Kosaka T e.a. Elevated cerebrospinal fluid tau protein level as a predictor of dementia in memory-impaired individuals. Alzheimer’s Res 1997; 3:211-213.

    Google Scholar 

  • Amieva H, Letteneur L, Dartiques JF e.a. Annual rate and predictors of conversion to dementia in subjects presenting with mild cognitive impairment criteria defined according to a population-based study. Dement Geriatr Cogn Disord 2004; 18:87-93

    Article  PubMed  Google Scholar 

  • Aggarwal NT, Wilson RS, Beck TL e.a. The apolipoprotein E epsilon4 allele and incident Alzheimer’s disease in persons with mild cognitive impairment. Neurocase 2005; 11:3-7

    Article  PubMed  Google Scholar 

  • Kryscio RJ, Schmitt FA, Salazar JC e.a. Risk factors for transitions from normal to mild cognitive impairment and dementia. Neurology 2006; 66:828-832

    Article  CAS  PubMed  Google Scholar 

  • Visser PJ, Verhey FRJ, Scheltens P e.a. Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects. J Neurol 2002; 249:312-319.

    Article  PubMed  Google Scholar 

  • Petersen RC, Thomas RG, Grundman M e.a. Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine 2005; 352:2379-2388

    Article  CAS  PubMed  Google Scholar 

  • Comijs HC, Deeg DJH, Dik MG e.a. Memory complaints; the association with psycho-affective and health problems and the role of personality characteristics. A 6-year follow-up study. J Affective Disord 2002; 72:157-165

    Article  CAS  Google Scholar 

  • Fratiglioni L, Paillard-Borg S, Winblad B. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 2004; 3:343-353

    Article  PubMed  Google Scholar 

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Correspondence to C. Jonker.

Additional information

gedragsneuroloog, VU medisch centrum, EMGO Instituut, Amsterdam

senior-onderzoeker, GGZ Buitenamstel/VU medisch centrum, Amsterdam

Correspondentie: Prof. Dr. C. Jonker, VU medisch centrum EMGO Instituut, Van de Boechorststraat 7-9,1081 BT Amsterdam. E-mail:c.jonker@vumc.nl

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Jonker, C., Comijs, H.C. Lichte Cognitieve Stoornissen (MCI): Prodromen van dementie?. GEEG 38, 104–110 (2007). https://doi.org/10.1007/BF03074837

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  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03074837

  • Mild Cognitive Impairment
  • MCI
  • predictoren
  • neuropsychiatrische verschijnselen