Skip to main content
SpringerLink
Log in

Vitamine B12 en cognitieve stoornissen bij ouderen

  • Artikelen
  • Published:
Neuropraxis

Abstract

Dementie is een ziekte van de oude mens. Het percentage van voorkomen loopt op van 1% bij 65-jarigen tot ruim 40% bij mensen van 90 jaar en ouder. De ziekte van Alzheimer, vasculaire dementie en dementie bij de ziekte van Parkinson zijn de meest voorkomende vormen van dementie. Slechts een klein percentage van de dementiesyndromen is potentieel reversibel met een prevalentie van ongeveer 13% (Clarfield, 1988).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatuur

  • Boushey C.J., Beresford S.A.A., Omenn G.S., Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. jama 1995;274:1049-1057.

    Google Scholar 

  • Clarfield A. The reversibel dementia: do they reverse? Ann Int Med 1988; 109:476-486.

    Google Scholar 

  • Clarke R., Smith A.D., Jobst K.A., et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-1455.

    Google Scholar 

  • Cole M.G., Prchal J.F. Low serum vitamin B12 in Alzheimer-type dementia. Age Ageing 1984; 1:101-105.

    Google Scholar 

  • Hector M., Burton J.R. What are the psychiatric manifestations of vitamin B12 deficiency? J Am Geriatr Soc 1988; 36:79-83.

    Google Scholar 

  • Hoffman A., Ott A., Breteler M.M.B., et al. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 1997;349:151-154.

    Google Scholar 

  • Joosten E., Lesaffre E., Riezler R. et al. Is metabolic evidence for vitamin B12 and folate deficiency more frequent in elderly with Alzheimer's disease? J Gerontol 1997;52: M76-M79.

  • Karnaze D.S., Carmel R. Low serum cobalamin levels in primary degenerative dementia. Arch Int Med 1987;147: 429-431.

    Google Scholar 

  • Kristensen M.O., Gulmann N.C., Christensen J.E.J., Ostergaard K., Rasmussen K. Serum cobalamin levels and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand 1993; 87:475-481.

    Google Scholar 

  • Riggs K.M., Spiro III A., Tucker K., Rush D. Relations of vitamin B12, vitamin B6, folate and homocysteine to cognitive function in the Normative Aging Study. Am J Clin Nutr 1996;63:306-314.

    Google Scholar 

  • Rosenberg I.H., Miller J.W. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992;55 (Suppl 6):1237S-1243S.

    Google Scholar 

  • Seshadri S., Beise A., Selhub J., et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-483.

    Google Scholar 

  • Van Asselt D.Z.B., van Staveren W.A., de Groot L.C.P.G.M., et al. The role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in Dutch older subjects. Am J Clin Nutr 1998; 68:320-334.

    Google Scholar 

  • Van Asselt D.Z., Pasman J.W., van Lier H.J., et al. Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons. J Gerontol 2001;56: M775-M779.

Download references

Author information

Authors and Affiliations

  1. www.bsl.nl/shop/neuropraxis-1387-5817.html

    Dineke van Asselt

Authors
  1. Dineke van Asselt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Asselt, D. Vitamine B12 en cognitieve stoornissen bij ouderen. NEPR 6, 73–76 (2002). https://doi.org/10.1007/BF03071020

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03071020

Search

Navigation