Skip to main content
SpringerLink
Log in

Fysiologie van de hemostase

  • Artikelen
  • Published:
Tijdschrift voor kindergeneeskunde

Abstract Summary

The physiological haemostasis comprises a balance between the formation and the breakdown of a clot at the right time and the right location. The essential parts of this process are formed by enough and well functioning platelets, that will upon activation close the rupture in de vessel wall. Furthermore, the coagulation process is initiated with the formation of a fibrin clot, a process that is controlled by the endogenous anticoagulation. Finally, the fibrinolysis breaks down this clot. All these processes and their interaction are described in this paper.

Samenvatting

De fysiologie van de hemostase omvat een precair evenwicht waarbij een stolsel op het juiste moment en op de juiste plaats moeten worden gevormd en afgebroken. De essentiële onderdelen van dit proces worden gevormd door voldoende en goed functionerende bloedplaatjes die aanvankelijk het gat in de bloedvatwand dichten. Daar bovenop wordt de stolling geïnitieerd met de vorming van een fibrinestolsel en dit proces wordt gecontroleerd door de endogene antistolling. Dit stolsel wordt vervolgens afgebroken door de fibrinolyse. De verschillende processen en hun interactie worden in dit artikel beschreven.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Literatuur

  • Lowe G. Virchow's triad revisited: abnormal flow. Pathophysiol Haemost Thromb. 2003;33:455-7.

    Article  PubMed  Google Scholar 

  • Carmeliet P, Collen D. Development and disease in proteinase-deficient mice. Role of the plasminogen, matrix metalloproteinase and coagulation system. Thromb Res. 1998;91:255-85.

    Article  CAS  PubMed  Google Scholar 

  • Remick D. Biological perspectives. Pathophysiology of sepsis. Am J Pathol. 2007;170:1435-44.

    Article  CAS  PubMed  Google Scholar 

  • Staton C, Lewis C. Angiogenesis inhibitors found within the haemostasis pathway. J Cell Mol Med. 2005;9:286-302.

    Article  CAS  PubMed  Google Scholar 

  • Mügge A, Förstermann U, Lichtlen PR. Platelets, endothelium-dependent responses and atherosclerosis. Ann Med. 1991; 23:545-50.

    Article  PubMed  Google Scholar 

  • Hermann M. Cyclooxygenase-2 and nitric oxide. J Cardiovasc Pharmacol. 2006;47:S21-5.

    Article  CAS  PubMed  Google Scholar 

  • Opal SM, Kessler CM, Roemisch J, Knaub S. Antithrombin, heparin, and heparin sulfate. Crit Care Med. 2002;30:S325-31.

    Article  CAS  PubMed  Google Scholar 

  • Dahlbäck B, Villoutreix BO. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol. 2005;25:1311-20.

    Article  PubMed  CAS  Google Scholar 

  • Lijnen HR, Collen D. Endothelium in hemostasis and thrombosis. Prog Cardiovasc Dis. 1997;39:343-50.

    Article  CAS  PubMed  Google Scholar 

  • Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. Int J Biochem Cell Biol. 2002;34:1508-12.

    Article  CAS  PubMed  Google Scholar 

  • Geet C van. Thrombopoiesis: new concepts. Verh K Acad Geneeskd Belg. 2004;66:5-24.

    PubMed  Google Scholar 

  • Geet C van, Freson K, Vos R de, Vermylen J. Hereditary thrombocytopenias. In: Gresele P, Page CP, Fuster V, Vermylen J, eds. Platelets in thrombotic and non-thrombotic disorders. Pathophysiology, pharmacology and therapeutics. Cambridge University Press, 2002. p. 515-27.

  • Geet C van, Freson K. The production of platelets. In: Arnout J, Gaetano G de, Hoylaerts M, et al., eds. Thrombosis: fundamental and clinical aspects. Leuven University Press, 2003. p. 16-36.

  • Gibbins JM. Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci. 2004;117:3415-25.

    Article  CAS  PubMed  Google Scholar 

  • Andrews RK, Berndt MC. Platelet physiology and thrombosis. Thromb Res. 2004;114:447-53.

    Article  CAS  PubMed  Google Scholar 

  • Groot E, Groot PG de, Fijnheer R, Lenting PJ. The presence of active von Willebrand factor under various pathological conditions. Curr Opin Hematol. 2007;14:284-9.

    Article  CAS  PubMed  Google Scholar 

  • Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res. 2006;99:1293-304.

    Article  CAS  PubMed  Google Scholar 

  • Bearer EL, Prakash JM, Li Z. Actin dynamics in platelets. Int Rev Cytol. 2002;217:137-82.

    Article  CAS  PubMed  Google Scholar 

  • Reed GL. Platelet secretory mechanisms. Semin Thromb Hemost. 2004;30:441-50.

    Article  CAS  PubMed  Google Scholar 

  • Jurk K, Kehrel BE. Platelets: physiology and biochemistry. Semin Thromb Hemost. 2005;31:381-92.

    Article  CAS  PubMed  Google Scholar 

  • Hoffman M, Monroe DM. A cell-based model of hemostasis. Thromb Haemost. 2001;85:958-65.

    CAS  PubMed  Google Scholar 

  • Hoffman M, Monroe DM, Roberts HR. Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII. Blood Coagul Fibrinolysis. 1998;9:S61-5.

    CAS  PubMed  Google Scholar 

  • Mann KG. Thrombin formation. Chest. 2003;124:4S-10.

    Article  CAS  PubMed  Google Scholar 

  • Schearer MJ. Vitamin K metabolism and nutriture. Blood Rev. 1992;6:92-104.

    Article  Google Scholar 

  • Lwaleed BA, Bass PS. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 2006;208: 327-39.

    Article  CAS  PubMed  Google Scholar 

  • Esmon CT. The protein C pathway. Chest. 2003;124:26-32.

    Article  Google Scholar 

  • Booth NA. Fibrinolysis and thrombosis. Baillieres Best Pract Res Clin Haematol. 1999;12:423-33.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. www.bsl.nl/shop/tydschrift-vkindergeneeskunde-0376-7442.html

    C. van Geet

Authors
  1. C. van Geet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Freson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. van Geet.

Additional information

Prof. dr. Chris van Geet, afdeling Kindergeneeskunde (Hemato-oncologie), Universitair Ziekenhuis Leuven, en Centrum voor Moleculaire en Vasculaire Biologie, ku Leuven. Prof. ir. Kathleen Freson, Centrum voor Moleculaire en Vasculaire Biologie, ku Leuven.

Correspondentieadres: Prof. dr. C. van Geet, afdeling Kindergeneeskunde (Hemato-oncologie), Universitair Ziekenhuis Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Geet, C., Freson, K. Fysiologie van de hemostase. KIND 75, 176–180 (2007). https://doi.org/10.1007/BF03061690

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03061690

Search

Navigation