Samenvatting
De afgelopen decennia zijn de genezingskansen voor kinderen met kanker gestegen van <30% in de jaren zestig tot momenteel >70%. Deze sterke verbetering is vooral te danken aan het toepassen van chemotherapie via internationale multicenter klinische trials en aan verbeterde ondersteunende maatregelen. Voortzetting van de internationale klinische trials en onderzoek naar efficiëntere ondersteunende zorg is dan ook geboden om deze hoge genezingskansen blijvend te waarborgen.
This is a preview of subscription content, log in via an institution to check access.
Relevante literatuur
Klinische trials en nieuwe behandelstrategieën
Tournade MF, Com-Nougue C, Kraker J de, et al. International Society of Pediatric Oncology Nephroblastoma Trial and Study Committee. Optimal duration of preoperative therapy in unilateral and nonmetastatic Wilms' tumor in children older than 6 months: results of the Ninth International Society of Pediatric Oncology Wilms' Tumor Trial and Study. J Clin Oncol 2001;19(2):488-500.
Buwalda J, Schouwenburg PF, Blank LE, et al. A novel local treatment strategy for advanced stage head and neck rhabdomyosarcomas in children: results of the AMORE protocol. Eur J Cancer 2003;39(11):1594-602.
Wetering MD van de, Woensel JB van. Prophylactic antibiotics for preventing early central venous catheter Gram-positive infections in oncology patients. Cochrane Database Syst Rev 2003;(2):CD003295.
Dalen EC van, Kremer LC, Caron HN. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev 2002:Cochrane Protocol.
Kwaliteit van leven-studies
Houtzager BA, Grootenhuis MA, Hoekstra-Weebers JE, et al. Psychosocial functioning in siblings of paediatric cancer patients one to six months after diagnosis. Eur J Cancer 2003;39(10):1423-32.
Houtzager BA, Grootenhuis MA, Last BF. Supportive groups for siblings of pediatric oncology patients: impact on anxiety. Psychooncology 2001;10(4):315-24.
Langeveld NE, Stam H, Grootenhuis MA, Last BF. Quality of life in young adult survivors of childhood cancer. Support Care Cancer 2002;10(8):579-600.
Late effecten na kinderkanker
Kremer LC, Dalen EC van, Offringa M, et al. Anthracycline-induced clinical heart failure in a cohort of 607 children:long-term follow-up study. J Clin Oncol 2001;19(1):191-6.
Langeveld NE, Ubbink MC, Last BF, et al. Educational achievement, employment and living situation in long-term young adult survivors of childhood cancer in the Netherlands. Psychooncology 2003;12(3):213-25.
Biologie van kindertumoren
Versteeg R, Schaik BD van, Batenburg MF van, et al. The human transcriptome map reveals extremes in gene density, intron length, GCcontent, and repeat pattern for domains of highly and weakly expressed genes. Genome Res 2003;13(9): 1998-2004.
Caron H, Schaik B van, Mee M van der, et al. The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 2001;291(5507):1289-92.
Molenaar JJ, Sluis P van, Boon K, et al. Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma. Genes Chromosomes Cancer 2003;36(3):242-9.
Author information
Authors and Affiliations
Corresponding author
Additional information
Prof.dr. H.N. Caron en dr. R. Versteeg, afdeling Kindergeneeskunde, Emma Kinderziekenhuis AMC, Amsterdam.
Correspondentieadres: Prof.dr. H.N. Caron, afdeling Kindergeneeskunde, Emma Kinderziekenhuis AMC, Postbus 22660, 1100 DD Amsterdam
Rights and permissions
About this article
Cite this article
Caron, H.N., Versteeg, R. Wetenschappelijk onderzoek in de kinderoncologie binnen het Emma Kinderziekenhuis AMC. KIND 72, 192–197 (2004). https://doi.org/10.1007/BF03061517
Issue Date:
DOI: https://doi.org/10.1007/BF03061517