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Osteoporose op de kinderleeftijd

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Tijdschrift voor kindergeneeskunde

Summary

Osteoporosis is characterised by reduced bone density, deterioration of the micro-architecture of bone, and increased fracture risk. Bone density in later life largely depends on peak bone mass achieved in young adulthood. A reduced bone density is associated with increased fracture risk in adults as well as in children. Idiopathic juvenile osteoporosis and osteogenesis imperfecta are examples of primary osteoporosis. In childhood, however, osteoporosis is more frequently a complication of a chronic disease or its treatment. Prevention and treatment of osteoporosis with for example calcium and vitamin D supplementation, bisphosphonates, growth hormone and the effects of training programs need further evaluation.

Samenvatting

Osteoporose wordt gekenmerkt door verminderde botdichtheid, een verslechtering van de microarchitectuur van het bot en een verhoogd fractuurrisico. De botdichtheid op oudere leeftijd wordt onder andere bepaald door de piekbotmassa die wordt bereikt op jongvolwassen leeftijd. Een verminderde botdichtheid is geassocieerd met een verhoogd fractuurrisico bij volwassenen en kinderen. Idiopathische juveniele osteoporose en osteogenesis imperfecta zijn voorbeelden van primaire osteoporose. Op de kinderleeftijd is osteoporose echter vaker het gevolg van een chronische ziekte of de behandeling van die ziekte. Preventie en behandeling van osteoporose met bijvoorbeeld calcium en vitamine-D-suppletie, bisfosfonaten, groeihormoon en de effecten van trainingsprogramma's behoeven nadere evaluatie.

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    I. M. van der Sluis

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  1. I. M. van der Sluis
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  2. S. M. P. F. de Muinck Keizer-Schrama
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Correspondence to I. M. van der Sluis.

Additional information

Dr. Inge M. van der Sluis, afdeling Kindergeneeskunde, subafdeling Endocrinologie, Erasmus MC/Sophia, Rotterdam.

Dr. Sabine M.P.F. de Muinck Keizer-Schrama, afdeling Kindergeneeskunde, subafdeling Endocrinologie, Erasmus MC/Sophia, Rotterdam.

Dr. I.M. van der Sluis, afdeling Kinderendocrinologie, Erasmus MC/Sophia, Postbus 2060, 3000 CB Rotterdam, tel: 010-4636111, fax: 010-4636811

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van der Sluis, I.M., de Muinck Keizer-Schrama, S.M.P.F. Osteoporose op de kinderleeftijd. KIND 71, 254–260 (2003). https://doi.org/10.1007/BF03061468

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