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Vragen rond de behandeling van hyperactiviteit met methylfenidaat

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Kind en adolescent

semenvatting

Dit artikel geeft een inleiding in de wetenschappelijke literatuur over de behandeling van hyperactiviteit met methylfenidaat (merknaam Ritalin). De effecten van dit medicijn blijken sterk individueel en gevarieerd. Bovendien zijn er enkele onopgeloste methodologische problemen. Een gevalsstudie bij een residentieel behandelde hyperactieve jongen illustreert de onzekerheden. Er wordt een aantal kwesties besproken die bij het voorschrijven van methylfenidaat twijfel wekken. Geconcludeerd wordt dat, ook al worden in groepsstudies effecten gevonden, het individueel voorschrijven van methylfenidaat enige scepsis verdient en dat effect–evaluatie direct gekoppeld zou moeten worden aan van te voren gespecificeerde doelstellingen.

Summary

This paper gives a scientific background to a number of aspects of the use of methylphenidate in hyperactivity. The results show that the effects are highly individual and varied. Some methodological problems remain unsolved. It illustrates the uncertainties with a case study. The conclusions are, in clinical practice, that the use of methylphenidate may be justified, but that objectives should be specified and effect evaluation should be carried out on the child's behaviour immediately.

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Figuur 1.
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Figuur 3a en 3b.
Figuur 4a, 4b en 4c.
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Literatuur

  • Achenbach, T.M. & Edelbrock, C.S. (1983). Manual for the child behavior checklist and revised child behavior profile. Burlington: University of Vermont.

    Google Scholar 

  • Connors, C.K. (1973). Rating scales for use in drug studies with children. Psychopharmacology Bulletin, 9, 24–84.

    Google Scholar 

  • Douglas, V.I. (1984). Attentional and cognitive problems. In M. Rutter (Ed.), Developmental neuropsychiatry (pp. 280–329). New York: The Guilford Press.

    Google Scholar 

  • Evans, R.W., Gualtieri, T. & Amara, J. (1986). Methylphenidate and memory: Dissociated effects in hyperactive children. Psychopharmacology , 90, 211–216.

    Article  CAS  PubMed  Google Scholar 

  • Gualtieri, T., Hicks, R.E., Patrick, K., Schroeder & Breese, G.R. (1984). Clinical correlates of methylphenidate blood levels. Therapeutic Drug Monitoring, 6, 379–392. New York: Raven Press.

    Google Scholar 

  • Gunning, W.B., Boer, J.E. de (1990). Aandachtsstoornissen en hyperactiviteit. In J.A.R. Sanders–Woudstra, & H.F.J. de Witte, (Red.), Leerboek kinder– en jeugdpsychiatrie (pp. 515–536). Assen: Van Gorcum.

    Google Scholar 

  • Handen, B.L., Breaux, A.M., Janosky, J., McAuliffe, S., Feldman, H. & Gosling, A. (1992). Effects and noneffects of methylphenidate in children with mental retardation and ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 455–461.

    Article  CAS  PubMed  Google Scholar 

  • Hoeks, J. (1985). Vaardigheden in begrijpend lezen. Academisch Proefschrift. Amsterdam: Universiteit van Amsterdam.

    Google Scholar 

  • Hungund, B.L., Perel, J.M., Hurwic, M.J., Sverd, J. & Winsberg, B.G. (1979). Pharmacokinetics of methylphenidate in hyperkinetic children. British Journal of Clinical Pharmacology, 8, 571–576.

    CAS  PubMed  Google Scholar 

  • Jacobvitz, D., Sroufe, A., Stewart, M. & Leffert, N. (1990). Treatment of attentional and hyperactivity problems in children with sympathicomimetic drugs: A comprehensive review. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 677–688.

    Article  CAS  PubMed  Google Scholar 

  • Kagan, J., Rosman, B.L., Day, D. Albert, J. & Philips, W. (1964). Information processing in the child. Significance of analytic and reflective attitudes. Psychological Monographs, 78, Whole No. 578.

    Google Scholar 

  • Kendall, P.C. & Fischler, G.L. (1983). Teaching rational self–talk to impulsive children. In A. Elles & M.E. Bernard (Eds.), Rational–emotive approaches to the problems of childhood (pp. 159–188). New York: Plenum Press.

    Google Scholar 

  • Kinsbourne, M. & Swanson, P.J. (1979). Children's learning and attention problems. Boston: Little, Brown.

    Google Scholar 

  • Meents, C.K. (1989). Attention Deficit Disorder: A Review of literature. Psychology in the Schools, 26, 168–178.

    Article  Google Scholar 

  • Offord, D.R., Boyle, M.H. & Racine, Y. (1991). Ontario child health study: Correlates of disorder. In S. Chess and M.E. Hertzig (Eds.), Annual progress in child psychiatry and child development (pp. 194–204). New York: Brunner/Mazel.

    Google Scholar 

  • Oosterbaan, H. (1989). Kendall & Wilcox's Self–Control Rating Scale administered to Dutch children. A challenge for science and practice in education and mental health. Lezing gepresenteerd op het PAOS–congres, Attention Deficit Hyperactivity Disorder, Vrije Universiteit Amsterdam.

  • Porges, S.W. (1976). Peripheral and neurochemical parallels of psychopathology: A psychophysiological model relating autonomic imbalance to hyperactivity, psychopathy and autism. In H.W. Reese (Ed.), Advances in child development and behavior (pp. 35–65). New York: Academic Press.

    Google Scholar 

  • Porges, S.W., Bohrer, R.E., Keren, G., Cheung, M.N., Franks, G.J. & Drasgow, F. (1981). The Influence of methylphenidate on spontaneous autonomic activity and behavior in children diagnosed as hyperactive. Psychophysiology, 18, 42–48.

    Article  CAS  PubMed  Google Scholar 

  • Quay, H.C. (1988). Attention deficit disorder and the behavioral inhibition system: The relevance of the neuropsychological theory of Jeffrey A. Gray. In L.M. Bloomingdale (Ed.), Attention deficit disorder. Criteria, cognition, intervention (pp. 176–186). Oxford: Pergamon.

    Google Scholar 

  • Rapport, M.D. (1990). Controlled studies of the effects of psychostimulants on childrens functioning in clinical and classroom settings. In K. Conners & M. Kinsbourne (Eds.), Attention deficit hyperactivity disorder (pp. 77–111). Munchen: MMV Medizin Verlag.

    Google Scholar 

  • Rapport, M.D., Stoner, G., Du Paul, G.J., Birmingham, B.K. & Tucker, S. (1985). Methylphenidate in hyperactive children: Differential effects of dose on academic learning, and social behavior. Journal of Abnormal Child Psychology, 13, 227–244.

    Article  CAS  PubMed  Google Scholar 

  • Redalieu, E.A. (1982). Study of Methylphenidate in man with respect to its major metabolite. Drug Metabolism and Disposition, 10, 707–709.

    Google Scholar 

  • Repertorium (1991). Overzicht van farmaceutische specialités. Utrecht: Nefarma.

  • Ross, A.O. (1981). Child Behavior Therapy (pp. 105–123). New York: John Wiley & Sons.

    Google Scholar 

  • Ross, D.M. & Ross, S.A. (1982). Hyperactivity. New York: Wiley & Sons.

    Google Scholar 

  • Sanders, A.F. (1983). Towards a model of stress and human performance. Acta Psychological, 53, 61–97.

    Article  CAS  Google Scholar 

  • Schachar, R. (1991). Childhood hyperactivity. Journal of Child Psychology and Psychiatry, 32, 155–191.

    Article  CAS  PubMed  Google Scholar 

  • Sergeant, J.A. (1990). Attention Models and the diagnosis of ADD. In K. Connors & M. Kinsbourne (Eds.), Attention Deficit Hyperactivity Disorder (pp. 121–126). München: MMV Medizin Verlag.

    Google Scholar 

  • Verhulst, F.C. (1985). Mental health in Dutch children: An epidemiological study. Academisch Proefschrift. Rotterdam: Erasmus Universiteit.

    Google Scholar 

  • Vlugt, H., van der & Feltzer, M.J.A. (1983). Hyperactiviteit. In J. de Wit, H. Bolle & M. van Meel (Red.), Psychologen over het kind. Deel 7 (pp. 31–60). Lisse: Swets & Zeitlinger.

    Google Scholar 

  • Wargin, W., Gualtieri, T., Kilts, C., Youngblood, W., Patrick, K. Mueller, R., Mailman, R. & Breese, G. (1981). The pharmacokinetics of methylphenidate in normal adult males. Federation Proceedings. Federation of American Society for Experimental Biology, 40, part 1.

  • Wargin, W., Patrick, K., Kilts, C., Gualtieri, T., Ellington, K., Mueller, R.A., Kralmer, G. & Breese, G.R. (1983). Pharmacokinetics of Methylphenidate in Man, Rat and Monkey. Journal of Pharmacology and Experimental Therapy, 226, 382–386.

    CAS  Google Scholar 

  • Weber, E.J.M. (1993). The child's heart beat. Developmental changes in heart rate and attention during middle childhood. Academisch proefschrift. Amsterdam: Universiteit van Amsterdam.

    Google Scholar 

  • Wolffers, I. (1992). Medicijnen. Amsterdam: Contact.

    Google Scholar 

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    M. M. T. Hendrikx

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  1. M. M. T. Hendrikx
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  2. E. J. M. Weber
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Mevr. drs. M.M.T. Hendrikx is klinisch psychologe en universitair docente bij de vakgroep Psychiatrie van de Universiteit van Amsterdam.

Mevr. drs. E.J.M. Weber is psychofysiologe en toegevoegd onderzoekster bij de vakgroep Ontwikkelingspsychologie van de Universiteit van Amsterdam.

Contactadres: Psychiatrisch Centrum, Tafelbergweg 25, 1105 AZ Amsterdam.

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Hendrikx, M.M.T., Weber, E.J.M. Vragen rond de behandeling van hyperactiviteit met methylfenidaat. KIAD 14, 66–73 (1993). https://doi.org/10.1007/BF03060502

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