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Factors influencing the distribution of antibody in the immunoglobulin classes of the mouse

Fattori che influenzano nel topo la distribuzione degli anticorpi nelle varie classi di immunoglobuline

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La Ricerca in Clinica e in Laboratorio

Riassunto

Anticorpi verso l’HSA e 1a KLH sono stati dimostrati in tutte e cinque 1e classi immunoglo-buliniche di topolini Balb/c. È stato dimostrato che 1aB. pertussis è più efficace nello stimolare 1a produzione di anticorpi verso l’HSA che verso 1a KLH e che gli anticorpi IgGi e IgG2b sono stimolati più di quelli delle altre classi. È stato inoltre dimostrato che i topolini timectomizzati producono meno anticorpi dei topolini normali verso l’HSA e che 1a riduzione délia quantità totale di anticorpi è dovuta ad una riduzione degli anticorpi IgGi.

Summary

Antibody activity against HSA and KLH has been found in all five Immunoglobulin classes of Balb/c mice.B. pertussis was more effective in stimulating antibody production against HSA than against KLH and IgG1 and IgG2b antibody were effected more than the antibody present in the other classes. It has also been showed that thymectomised mice produced a significant lower level of antibody against HSA and the decrease in the total antibody was due to a decrease in IgG1 antibody.

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  1. DEpartment of Immunology Middlesex Hospital Medical School, Immunology Unit World Health Organization Geneva, LONDON, Switzerland

    Giorgio Torrigiani

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  1. Giorgio Torrigiani
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Torrigiani, G. Factors influencing the distribution of antibody in the immunoglobulin classes of the mouse. La Ricerca Clin. Lab. 1, 530–541 (1971). https://doi.org/10.1007/BF03054475

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  • DOI: https://doi.org/10.1007/BF03054475

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