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Biosintesi in vitro delle gammaglobuline nel mieloma multiplo e nella sindrome macroglobulinemica di Waldenström

In vitro biosynthesis of gamma globulins in multiple myeloma and in waldenström Macroglobulinemia

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La Ricerca in Clinica e in Laboratorio

Riassunto

Gli AA. hanno studiatoin vitro, in un gruppo di pazienti affetti da mieloma multiplo e da sindrome macroglobulinemica di Waldenström, 1a sintesi delle frazioni gammaglobuliniche da parte del midollo osseo e dei linfociti del sangue periferico. È stato dimostrato che 1e cellule del midollo osseo di questi pazienti sono in grado di sintetizzarein vitro una componente omogenea a mobilità elettroforetica ed a determinante antigenica eguale a quella presente nel siero. È stato rilevato che il midollo osseo in corso di mieloma produce altre componenti omogenee non osservabili nel siero ed infine è stato dimostrato che 1a sindrome da carenza di anticorpi in questi pazienti è dovuta a deficit nella produzione delle altre frazioni non mielomatose.

Summary

The authors investigated the synthesis of gammaglobulins by bone marrow cells and lymphocytes of blood in some patients with multiple myeloma and Waldenström’s macroglobulinemia. They demonstrated that bone marrow cells of these patients can synthetizein vitro a homogeneous component which electrophoretically and antigenically appears similar to that present in blood. Furthermore produces other homogeneous components not present in serum. Antibody deficiencies in multiple myeloma are due to deficit in production of the non myelomatous gamma-globulinic fractions.

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Authors and Affiliations

  1. Istituto di I Clinica dette Malattie Infettive, dett’Università di Roma, 00161, Roma - Italy

    Luigi Fontana, Fernando Aiuti & Franco de Rosa

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  1. Luigi Fontana
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  2. Fernando Aiuti
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  3. Franco de Rosa
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Fontana, L., Aiuti, F. & de Rosa, F. Biosintesi in vitro delle gammaglobuline nel mieloma multiplo e nella sindrome macroglobulinemica di Waldenström. La Ricerca Clin. Lab. 1, 333–361 (1971). https://doi.org/10.1007/BF03054465

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