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The molecular basis of the biologic function of complement

Basi Molecolari Della Funzione Biologica del Complemento

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  • Published:
La Ricerca in Clinica e in Laboratorio

Conclusions

Complement research has entered the phase of intense biochemical and biomedical investigation. New insights have already been derived from this work regarding the assembly of multi-molecular functional units, the manner in which biological membranes may be impaired and the generation of biologic activity through dissociation of low molecular weight cleavage products. With increasing biochemical understanding the complexity of complement is becoming less bewildering. The operational subdivision of the system into an activation and an attack mechanism may be a meaningful clue for the elucidation of the phylogenetic evolution of complement. The recognition of regulatory mechanisms in the form of inhibitors and inactivators has stressed the potential biological significance of complement. Most importantly, definite progress has been made in studying the biologic function of complementin vivo. Work on disease models and clinical investigations have yielded results strongly supporting the view that complement has effector functionsin vivo. If the present momentum of complement research continues, then much will be learned from developments of the next few years.

Conclusioni

Gli studi sul complemento sono entrati in una fase di intensa ricerca biochimica e biomedica. Da questo tipo di lavoro sono scaturiti nuovi dati relativi a: 1) alla formazione di unità funzionali multimolecolari; 2) alle modalità attraverso le quali le membrane cellulari vengono alterate; 3) alla formazione di attività biologiche attraverso la produzione di frammenti di piccolo peso molecolare. Con il miglioramento delle conoscenze biochimiche, la complessità del complemento risulta sempre meno sconcertante. La suddivisione operativa del sistema in un meccanismo di attivazione ed uno di attacco può rappresentare un ottimo sistema per la comprensione della evoluzione filogenetica del complemento. L’identificazione di meccanismi di regolazione sotto forma di inibitori o di inattiyatori ha accentuato il significato biologico Potenziale del complemento. Inoltre, fatto ancora più importante, significativi progressi sono stati fatti nello studio della funzione biologica del complementoin vivo. Dati derivanti da modelli di malattie sperimentali e da studi clinici hanno fornito risultati che avvalorano l’ipotesi che il complemento svolgain vivo funzioni effettrici. Se le ricerche sul complemento continueranno con la stessa vivacità di ora, gli sviluppi dei prossimi anni potranno darci molti insegnamenti.

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    Hans J. Müller-Eberhard

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This is publication number 411 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

This work was supported by United States Public Health Service Grant AI-07007, American Heart Association, Inc. Grant 68-666 and United States Atomic Energy Commission Contract AT(04-3)-730.

Il presente articolo, pubblicato nelTrattato di Immunologia, edito dalla Casa Editrice Flammarion, è stato tradotto per gentile concessione dell’Autore e dell’Editore.

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Müller-Eberhard, H.J. The molecular basis of the biologic function of complement. La Ricerca Clin. Lab. 1, 60–109 (1971). https://doi.org/10.1007/BF03054454

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