Summary
The alterations in rat serum proteins resulting from (i) variations in dietary protein quality and level, (ii) minimal intakes of B vitamins and (iii) single and combined deficiencies of vitamin B12 and folic acid have been studied with egg albumin, casein and peanut protein diets at 10 and 18 per cent. protein levels.
Protein quality chiefly influences serum concentrations of albumin andα 1-globulin, the effects on other fractions being variable. Protein level affects serum levels of albumin,α 1-globulin andα 2-globulin. The effects due to these dietary variables are interdependent.
Variations in dietary protein quality do not alter the relative distribution of serum protein fractions. Changes in protein level cause shifts in the relative distribution of globulins, the albumin-globulin ratio remaining unaltered.
The nature and extent of changes in serum protein profile due to vitamin insufficiencies or deficiencies are also influenced, qualitatively and quantitatively, by dietary amino acids. With minimal intakes of B vitamins γ-globulin is chiefly reduced, but other fractions, particularlyα 1-globulin, may also be affected. In a combined deficiency of vitamin B12 and folic acid a common reduction inγ-globulin is variably attended by reductions in albumin and inα 1- andβ-globulins. In single vitamin B12 deficiency, the changes are confined to albumin,α 1-globulin andα 2-globulin fractions, whereas single folic acid deficiency chiefly affectsγ-globulin with variable effects on albumin andβ-globulin fractions.
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Mulgaonkar, A.G., Sreenivasan, A. Alterations in rat serum proteins in relation to dietary proteins and B vitamins. Proc. Indian Acad. Sci. 49, 408–419 (1959). https://doi.org/10.1007/BF03053877
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DOI: https://doi.org/10.1007/BF03053877