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Chromosome breakage and enhancement in radiation sensitivity induced by 5-trifluoromethyl-2-deoxy-uridine inVicia faba

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Proceedings / Indian Academy of Sciences

Abstract

The effect of 5-trifluoromethyl-2-deoxyuridine (F3TdR) on the frequency of X-ray-induced chromosomal aberrations has been discussed. F3TdR is a potent chromosome-breaking agent and its chromosome-breaking ability is concentration-dependent. F3TdR sensitizes the system to radiation and increases the frequency of X-ray-induced chromosomal aberration. The radio-sensitization is also concentration dependent. The occurrence of a large number of gaps in both chromatids and chromosomes in chemical-cum-radiation combination treatment supports the idea that the sensitization to radiation results from halogenation following the incorporation of F3TdR in DNA.

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Authors and Affiliations

  1. Division of Botany, Indian Agricultural Research Institute, New Delhi-12

    R. P. Sharma

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  1. R. P. Sharma
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Communicated by Dr. M. S. Swaminathan,f.a.sc.

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Sharma, R.P. Chromosome breakage and enhancement in radiation sensitivity induced by 5-trifluoromethyl-2-deoxy-uridine inVicia faba . Proc. Indian Acad. Sci. 64, 22–25 (1966). https://doi.org/10.1007/BF03052397

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  • DOI: https://doi.org/10.1007/BF03052397

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