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Pyrimidines as possible oncolytic agents

Part I. 2-amino-4-hydroxy-5-(β-hydroxyethyl)-6-alkyl-pyrimidines and 6-alkyl-5-(β-hydroxyethyl)-2-thiouracils

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Abstract

Two series of 5-(β-hydroxyethyl)-6-alkyl pyrimidines have been synthesised and thirty new compounds reported. Two of the pyrimidines have been found to possess significant tumour inhibitory activity against a solid rat tumour. No relationship between the length of alkyl chain at position ‘6’ in the compounds and their tumour inhibitory activity was observed.

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Authors and Affiliations

  1. Chemotherapy Section, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay-12

    M. V. Wagle & T. B. Panse

Authors
  1. M. V. Wagle
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  2. T. B. Panse
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Additional information

Communicated by Dr. V. R. Khanolkar,f.a.sc.

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Wagle, M.V., Panse, T.B. Pyrimidines as possible oncolytic agents. Proc. Indian Acad. Sci. 68, 277–284 (1968). https://doi.org/10.1007/BF03051926

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  • DOI: https://doi.org/10.1007/BF03051926

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