Skip to main content
SpringerLink
Log in

Role of N-Nitrosodimethylamine (NDMA) as a carcinogenic agent for tumours of nasal cavities in workers of leather industry

  • Original / Main Article
  • Published:
Indian Journal of Otolaryngology and Head and Neck Surgery Aims and scope Submit manuscript

Abstract

The chemical used during leather tanning Dimethylene Sulphate (DMS) is nitrosated, perhaps, by Oxides of Nitrogen in air, to produce N-Dimethyl-nitosamine (NDMA) which has been proved to be carcinogenic to various body organs including nasal cavity. This study was aimed at finding the incidence of nasal tumuors in leather tanning workers and to campare with that of general population to ascertain if nitrosamines are significant occupational hazardous agents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bogovski, P., Preussmann, R. and Walker, E. A. (Eds.) (1972)*: -N-Nitroso compounds analogues and formation. Lyon France: I. A. R. C.

    Google Scholar 

  2. Bogovski, P., Preussmann, R. and Walker, E. A. (Eds.) (1975)*: -N-Nitroso compounds in the environment. Lyon France: I. A. R. C.

    Google Scholar 

  3. Brugoch, H. & Elkins, H. — (1963): Toluene diisocyanate ToxicityN. Eng. J. Med. 268, 353

    Article  Google Scholar 

  4. Ghosh, B. N. (1969): A Treaties on Hygiene and public health, Scientific Publishing Co. Calcutta p. 158, 15th Ed.

    Google Scholar 

  5. Hoffman, D., Hect, R. M., Wynder, E. L. et al (1975)* — Chemical Studies on tobacco smoke: XLII — Lyon France: I. A. R. C.

    Google Scholar 

  6. I. A. R. C. monographs on the evaluation of carcinogenic risks of chemicals to man* i)VOL I: Lyon France: International Agency for research in cancer 1972. ii) Some aromatic amines, Hydrazine and related substances, N-Nitroso compounds and misc, alkylating agentsVOL. 4, Lyon, France: International Agency for research in cancer 1974. iii) Some N-Nitroso compounds Vol. 17, Lyon, France: International Agency for research in cancer 1978.

  7. Nicholson, W. J. (1983): Environmental and occupational medicine, Little Brown & Co. Boston Ist Ed. P. 613.

    Google Scholar 

  8. Rounbehler, D. P., Krull, I. S. & Goff, E. U., et al (1979)*: Exposure to N-Nitrosodimethylamine in a leather tannery. Food cosmet. Toxicolol17: 487.

    CAS  Google Scholar 

  9. Walker, E. A., Bogovoski, P. & Griciuce, L. (Eds)1976*: — Environmental N-Nitroso compounds — Analogues and formation. Lyon France I. A. C. R.

    Google Scholar 

  10. Walker, E. A., Castegnaro, M., Gricinte, L. et al (Eds) (1978)*: Environmental aspects of N-Nitroso compounds Lyon, France: I. A. C. R. * Quoted by — Nicholson, W. J. in Environmental and Occupational medicine, Little Brown & Co. Boston Ist. ed. 1983.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of E.N.T., Maulana Azad Medical College, India

    N. Sinha, P. K. Kakar, A. K. Agarwal & R. Bansal

  2. L. N. J. P. N., India

    N. Sinha, P. K. Kakar, A. K. Agarwal & R. Bansal

  3. G. B. Pant Hospital, 110002, New Delhi

    N. Sinha, P. K. Kakar, A. K. Agarwal & R. Bansal

Authors
  1. N. Sinha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. K. Kakar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. K. Agarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Bansal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sinha, N., Kakar, P.K., Agarwal, A.K. et al. Role of N-Nitrosodimethylamine (NDMA) as a carcinogenic agent for tumours of nasal cavities in workers of leather industry. Indian J Otolaryngol Head Neck Surg 45, 10–12 (1993). https://doi.org/10.1007/BF03051616

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03051616

Keywords

Search

Navigation