Skip to main content
SpringerLink
Log in

Chemotherapy of bacterial infections

Part II. Synthesis of some sulphanilamide derivatives and the relation of chemical constitution to chemotherapeutic action

  • Published:
Proceedings of the Indian Academy of Sciences - Section A Aims and scope Submit manuscript

Summary

The synthesis and the chemotherapeutic effects in experimentalstreptococcal andpneumococcal infections in mice of new sulphanilamide derivatives are described. 2-N1 sulphanilamidothiazol appears to possess a very striking effect in these infections.

The realtionship of chemical constitution to chemotherapeutic action in this group of compounds has been outlined basing on a study of the therapeutic properties of about 500 compounds till now reported. While the substitution at the amino radical of sulphanilamide does not produce compounds of increased activity but only suppress the polyvalent action of the original compound, the substitution at the amide part of the molecule, especially by a heterocyclic ring, produces compounds of increased activity, particularly in infections in which sulphanilamide is very little effective. The highly active diaminodiphenylsulphone derivatives have to be properly modified to be used in practical therapy. There does appear to be a sort of specificity of the compounds towards different types of infections so that the new compounds produced should be tested in different types of infections also.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ganapathi, K...J. Indian Chem. Soc., 1938,15, 525.

    Google Scholar 

  2. —..Curr. Sci., 1938,6, 608.

    Google Scholar 

  3. - ..Indian J. Med. Res. (under publication in the April Issue).

  4. Crossley, Northey and HultquistJ. Amer. Chem. Soc., 1938,60, 2217.

    Article  Google Scholar 

  5. Dochez and Slauetz..Science, 1938,87, 142.

    Article  Google Scholar 

  6. Plummer, Mitchell and WalkerCanad. J. Compar. Med., 1938,2, 139.

    Google Scholar 

  7. McIntyre and MontgomerieBrit. Med. J., 1938,1, 878.

    Google Scholar 

  8. McCrea..Amer. J. Physiol., 1939,126, 569.

    Google Scholar 

  9. Hebb, Sullivan and FeltonPub. Hlth. Rep. U.S., 1939,54, 1750.

    Google Scholar 

  10. Whitby, L. E. H...Lancet, 1937,1, 1517.

    Article  Google Scholar 

  11. Bauer and Rosenthal..Pub. Hlth. Rep. U.S., 1938,53, 40.

    Google Scholar 

  12. Bauer, H...J. Amer. Chem. Soc., 1939,61, 613.

    Article  Google Scholar 

  13. Cooper, Gross and LewisProc. Soc. Exp. Biol. & Med., 1938,38, 375.

    Google Scholar 

  14. Buttle, Dewing, Foster, Gray, Smith and StephensonBiochem. J., 1938,32, 1101.

    Google Scholar 

  15. Cooper, Gross and LewisJ. Chemotherapy, 1938,15, 31.

    Google Scholar 

  16. Grutz..Munch. Med. Wsch., 1937,84, 1201.

    Google Scholar 

  17. Domagk, G...Klin. Wsch., 1937,16, 1412.

    Article  Google Scholar 

  18. De and Basu..Indian J. Med. Res., 1938,26, 537.

    Google Scholar 

  19. Gray, W. H. ..J. Chem. Soc., 1939, 1202.

  20. Fourneau, Trefouel (M. & Mme.), Nitti and BovetC. R. Soc. Biol., 1938,127, 393.

    Google Scholar 

  21. Mc Leod, M...Biochem., J. 1938,32, 1770.

    Google Scholar 

  22. Rosenthal, Bauer and FloovePub. Hlth. Rep. U.S., 1939,54, 1317.

    Google Scholar 

  23. Kolmer, Brown and RaizissJ. Pharm. & Exp. Ther., 1937,61, 253.

    Google Scholar 

  24. Mayer and OeschstrossC. R. Soc. Biol., 1939,130, 211.

    Google Scholar 

  25. Mayer, L...C. R. Acad. Sci., Paris, 1937,205, 181.

    Google Scholar 

  26. Buttle, G. A. H...Brit. Med. J., 1939,11, 269.

    Article  Google Scholar 

  27. Fischer..Arch. Inter. Pharmacodynami, 1937,56, 131.

    Google Scholar 

  28. Miller, Rock and MooreJ. Amer. Chem. Soc., 1939,61, 1198.

    Article  Google Scholar 

  29. Gray, Buttle and StephensonBiochem. J., 1937,31, 724.

    Google Scholar 

  30. Trefouel (M. & Mme.), Nitti and BovetAnn. Inst. Pasteur, Paris, 1937,58, 30.

    Google Scholar 

  31. Adams, Long and JohansonJ. Amer. Chem. Soc., 1939,61, 2346.

    Article  Google Scholar 

  32. Gley, P...C. R. Acad. Sci., Paris, 1937,204, 1907.

    Google Scholar 

  33. Rosenthal, S. M...Pub. Hlth. Rep. U.S., 1937,52, 48.

    Google Scholar 

  34. Fourneau, Trefouel (M.), Nitti, Bovet and Trefouel (Mme.)C. R. Acad. Sci., Paris, 1937,204, 1763.

    Google Scholar 

  35. Buttle, Stephenson, Smith, Dewing and FosterLancet, 1937,1, 1331.

    Article  Google Scholar 

  36. Fourneau, Trefouel (M. & Mme.), Nitti and BovetC. R. Acad. Sci., Paris, 1937,205, 299.

    Google Scholar 

  37. —..C. R. Soc. Biol., 1936,122, 299.

    Google Scholar 

  38. Adams, Long and JohansonJ. Amer. Chem. Soc., 1939,61, 2342.

    Article  Google Scholar 

  39. Dohrn and Diedrich..Munch. Med. Wschr., 1938,85, 2017.

    Google Scholar 

  40. Crossley, Northey and HultquistJ. Amer. Chem. Soc., 1939,61, 2950.

    Article  Google Scholar 

  41. —..Ibid., 1938,60, 2222.

    Article  Google Scholar 

  42. Whitby, L. E. H...Lancet, 1938,1, 1210.

    Article  Google Scholar 

  43. a. Fosbinder and WalterJ. Amer. Chem. Soc., 1939,61, 2032.

    Article  Google Scholar 

  44. b. Rao and Ganapathi .. Under publication.

  45. Molitor and RobinsonJ. Pharm. & Exp. Ther., 1937,65, 405.

    Google Scholar 

  46. Marshall, E. K...Physiol. Rev., 1939,19, 253.

    Google Scholar 

  47. Trefouel (M. & Mme.), Nitti and BovetAnnales Medico-Chururgi, 1938, No. 3, 68.

  48. Holmann and Duff..Amer. J. Med. Sci., 1938,195, 379.

    Article  Google Scholar 

  49. a. Trefouel (M. & Mme.), Nitti and BovetC. R. Soc. Biol., 1935,120, 756.

    Google Scholar 

  50. b. Goissedet, Despois, Gailloit and MayerIbid., 1936,121, 1802.

    Google Scholar 

  51. c. Nitti and Bovet..C. R. Acad. Sci., Paris, 1936,202, 1221.

    Google Scholar 

  52. d. Fuller..Lancet, 1937,1, 194.

    Article  Google Scholar 

  53. e. Ganapathi and Rao .. Under publication.

  54. Buttle, Gray and StephensonLancet, 1936,1, 1286.

    Article  Google Scholar 

  55. Rosenthal, Wooley and BauerPub. Hlth. Rep. U.S., 1937,52, 1211.

    Google Scholar 

  56. Levaditi, Girard, Vaisman, Ray and RechiC. R. Acad. Sci., Paris, 1937,205, 1018.

    Google Scholar 

  57. Webster and Powers..J. Amer. Chem. Soc., 1938,60, 1553.

    Article  Google Scholar 

  58. Bobranski, B...Arch. Pharm., 1939,277, 75.

    Article  Google Scholar 

  59. Diels and Stamm..Ber., 1912,45, 2228.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Haffkine Institute, Parel, Bombay

    K. Ganapathi

Authors
  1. K. Ganapathi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Communicated by Lieut.-Col. S. S. Sokhey,m.d., i.m.s.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ganapathi, K. Chemotherapy of bacterial infections. Proc. Indian Acad. Sci. 11, 298–311 (1940). https://doi.org/10.1007/BF03051346

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03051346

Keywords

Search

Navigation