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The effect of a single injection of thyroxin on the protein and nucleic acids of the mouse liver and the protein of the mouse carcass

  • Published:
Proceedings / Indian Academy of Sciences

An Erratum to this article was published on 01 August 1952

Summary

  1. 1.

    Observations have been made concerning the effect of a single dose of thyroxin at a level of 4 mg. per kg. of body weight on the changes in the liver protein and nucleic acids at definite intervals in C-57 strain of mice.

  2. 2.

    Except for a marked drop in the liver RNA 6 hours after thyroxin administration, mobilisation of liver protein and nucleic acids take place during a period of active metabolism (18–120 hours after thyroxin administration). Some clear changes in the liver DNA have been also observed during the period of active metabolism.

  3. 3.

    There appears to be no quantitative correlation between the mobilisation of protein in the liver and loss of carcass protein, 96 hours after the administration of thyroxin.

  4. 4.

    The significance of the observed changes has been presented without prejudice or postulate.

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Author information

Authors and Affiliations

  1. Division of Laboratories, Tata Memorial Hospital, Bombay

    A. J. Baxi, Kumud D. Samarth & P. R. Venkataraman

Authors
  1. A. J. Baxi
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  2. Kumud D. Samarth
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  3. P. R. Venkataraman
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Additional information

Communicated by Dr. V. R. Khanolkar,m.d. (Lond.),f.a.sc.

An erratum to this article is available at http://dx.doi.org/10.1007/BF03050182.

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Baxi, A.J., Samarth, K.D. & Venkataraman, P.R. The effect of a single injection of thyroxin on the protein and nucleic acids of the mouse liver and the protein of the mouse carcass. Proc. Indian Acad. Sci. 34, 258–266 (1951). https://doi.org/10.1007/BF03050681

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  • DOI: https://doi.org/10.1007/BF03050681

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