Skip to main content
SpringerLink
Log in

Antitumor immunity in rats against Yoshida ascites sarcoma after treatment with antibiotics

  • Published:
Proceedings / Indian Academy of Sciences

Abstract

Chromomycin A3, mithramycin, olivomycin and actinomycin D, four antitumor antibiotics inhibit growth of Yoshida ascites sarcoma (YAS). The antibiotic treated tumor-free rats exhibit antitumor immunity as judged by rejection of subsequent tumor transplant. The lymphocytes from immune rats are able to inhibit tumor growth in syngenic animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Eagle, H., Amino acid metabolism in mammalian cell culture.Science 130 432–437 (1959).

    Article  PubMed  CAS  Google Scholar 

  2. Gause, G. F., Olivomycin, mithramycin and chromomycin: three related cancerostatic antibiotics.Adv. Chemother. 2 179–195 (1965).

    PubMed  CAS  Google Scholar 

  3. Goldberg, I. H. and Friedmann, P. A., Antibiotics and nucleic acids.Ann. Rev. Biochem. 40 775–810 (1971).

    Article  PubMed  CAS  Google Scholar 

  4. Imai, Y., Ochiai, H., Takizawa, H., Shigeno, N. and Kobayashi, Y., Influence of anticancer drugs on antibody formation in tumor-bearing mice demonstrated by antibody plaque technique.Nigata Igakkai Zasshi 84 715–731 (1970).

    CAS  Google Scholar 

  5. Kersten, W. and Kersten, H., Interaction of antibiotics with nucleic acids. InMolecular Association in Biology (Ed. B. P. Pullman), New York: Academic Press, pp. 289–298 (1968).

    Google Scholar 

  6. Lyashenko, V. A. and Koleshnikova, L. P., Effectof anticancer antibiotics on the formation of haemolysins.Antibiotiki 10 808–816 (1965).

    CAS  Google Scholar 

  7. Mathe, G., Active immunotherapy,Adv. Cancer. Res.,14 1–36 (1971).

    Article  PubMed  CAS  Google Scholar 

  8. Nayak, R., Prasad, K. S. and Sirsi, M., Immunosuppressive properties of antitumor antibiotic chromomycin A3.Proceedings of 42nd Annual Meeting, Society of Biological Chemists (India),32 30 (1973).

    Google Scholar 

  9. Prasad, K. S., Nayak, R., Sirsi, M. and Ramakrishnan, T., Role of mithramycin in immune response.Proceedings of 42nd Annual Meeting, Society of Biological Chemists (India),32 30 (1973).

    Google Scholar 

  10. Rao, V. S. and Sirsi, M., Humoral antibodies in the host directed against tumor cells after suppression of ascites tumor by heteroimmune sera.Cancer. Res. 31 1153–1158 (1971).

    PubMed  CAS  Google Scholar 

  11. Reddy, V. V. S. and Sirsi, M., Effect ofAbrus precatorius L. on experimental tumors.Cancer Res. 29 1447–1451 (1969).

    PubMed  CAS  Google Scholar 

  12. Reddy, V. V. S., Jayaram, H. N., Sirsi, M. and Ramakrishnan, T., Inhibitory activity of L-asparaginase fromMycobacterium tuberculosis on Yoshida ascites sarcoma of rats.Arch. Biochem. Biophys. 132 262–267 (1969).

    Article  PubMed  CAS  Google Scholar 

  13. Smith, R. T., Potentials for immunological intervention in cancer. InProgress in Immunology (Ed. Amos, B)., New York: Academic Press 1118–1129 (1971).

    Google Scholar 

  14. Yoshida, T., Comparative studies of ascites hepatoma. InMethods in Cancer Research (Ed. Busch, H), New York: Academic Press pp. 97–157 (1971).

    Google Scholar 

Download references

Author information

Author notes

  1. R. Nayak

    Present address: Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, 10032, New York, USA

Authors and Affiliations

  1. Microbiology and Cell Biology Laboratory, Indian Institute of Science, 560012, Bangalore

    R. Nayak & M. Sirsi

Authors
  1. R. Nayak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Sirsi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nayak, R., Sirsi, M. Antitumor immunity in rats against Yoshida ascites sarcoma after treatment with antibiotics. Proc. Indian Acad. Sci. 82, 132–138 (1975). https://doi.org/10.1007/BF03050526

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03050526

Keywords

Search

Navigation