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A blood anticoagulant factor from the latex ofCarica papaya

Part II. Its nature of action on blood coagulation

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Proceedings / Indian Academy of Sciences

Summary

A detailed investigation has been carried out on the mode of action of the anticoagulant factor present in the latex ofCarica papaya.

The dual function of the anticoagulant factor,viz., the inhibition of the conversion of prothrombin to thrombin, and the destruction of thrombin activity has been established.

It has been found that the iodacetate treatment destroys the antithrombin activity of the anticoagulant factor. However, the iodacetatetreated anticoagulant factor inhibits the formation of a perfect fibrin clot from plasma, even in the presence of active thrombin, probably through complex formation with the fibrinogen of the plasma. The possibility of the presence of a co-factor in plasma which promotes this complex formation is also envisaged.

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References

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Authors and Affiliations

  1. Department of Biochemistry, Indian Institute of Science, Bangalore-3

    N. C. Pillai, C. S. Vaidyanathan & K. V. Giri F.A.Sc.

Authors
  1. N. C. Pillai
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  2. C. S. Vaidyanathan
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  3. K. V. Giri F.A.Sc.
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Pillai, N.C., Vaidyanathan, C.S. & Giri, K.V. A blood anticoagulant factor from the latex ofCarica papaya . Proc. Indian Acad. Sci. 43, 46–54 (1956). https://doi.org/10.1007/BF03050218

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  • DOI: https://doi.org/10.1007/BF03050218

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