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Search for physiologically active compounds

Part XIII. Synthesis of some 3-amino-4-hydroxy coumarins and coumarino (3 : 4) oxazoles as analogues of novobiocin

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Abstract

A number of 3-amino-4-hydroxy coumarins substituted in the benzene ring have been synthesised by two methods starting from 4-hydroxy coumarins, one by nitration and reduction, and the other by diazotisation-coupling and reduction. The amino hydroxy coumarins have been converted into the corresponding (3 : 4) oxazoles by condensation with aromatic aldehydes. The ultraviolet and infrared spectral data as well as their bacteriostatic and fungistatic properties are presented.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad-7, A.P.

    K. S. R. Krishna Mohan Rao & N. V. Subba Rao F.A.Sc.

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  1. K. S. R. Krishna Mohan Rao
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  2. N. V. Subba Rao F.A.Sc.
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Rao, K.S.R.K.M., Rao, N.V.S. Search for physiologically active compounds. Proc. Indian Acad. Sci. 67, 42–49 (1968). https://doi.org/10.1007/BF03049933

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  • DOI: https://doi.org/10.1007/BF03049933

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