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Use of mitomycin C in endo-DCR

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Abstract

Objective: To evaluate the role of topical Mitomycin C in Endoscopic Dacryocystorhinostomy (DCR), for the prevention of stomal stenosis.Patients: Thirty patients undergoing endoscopic DCR for chronic dacryocystitis were studied prospectively. The follow up period was 12 months.Technique: Patients were divided into two groups randomly. All of them underwent endoscopic DCR. One group was subjected to topical Mitomycin C application after surgery while the control group was not.Main outcome measures: Postoperative relief of epiphora and endoscopic documentation of the patency of the stoma were the main outcome measures.Results: 80% cases of the Mitomycin C group and 86.67% cases of the non Mitomycin C group had long-term successful results. This result is not statistically significant (p> 0.2).Conclusion: Intraoperative Mitomycin C application does not alter the long-term results in endoscopic DCR. A properly and adequately performed surgery is more vital for successful result.

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References

  1. Beloglazov V G, Grusha O V, Saad-El’din NM, At’kova EL, Malaeva L V. (1999):The prevention and treatment of recurrences after dacryorhinostomies.Vestn Oftalmol. 115(5):14–7.

    PubMed  CAS  Google Scholar 

  2. Cummings J, Spanswick V J, Tomasz et al. (1998):Enzymology of Mitomycin C metabolic activation in tumour tissue: implications for enzyme directed bioreductive drug development.Biochem Pharmacol. 56:405–414.

    Article  PubMed  CAS  Google Scholar 

  3. Jampel HD. (1992):Effect of brief exposure to Mitomycin C on viability and proliferation of cultured human Tenon’s capsule fibroblasts.Opthalmology 99:1471.

    CAS  Google Scholar 

  4. Keerl R, Weber R. (2004):Dacryocystorhinostomy — State Of The Art, Indications, Results.Laryngorhinootologie.83(1):40–50.

    Article  PubMed  CAS  Google Scholar 

  5. Khaw PT, Sherwood MB, Rossi MJ, Schultz G. (1992):Five minute treatments with fluorouracil, floxuridine and Mitomycin have long term effect on human tenon’s capsule fibroblasts.Arch Ophthalmol. 110:1150.

    PubMed  CAS  Google Scholar 

  6. Liao S L, Kao SC, Tseng J H, Chen M S, Hou PK.(2000):Results of intraoperative mitomycin C application in dacryocystorhinostomy.Br. J Ophthalmol. 84(8):903–6.

    Article  PubMed  CAS  Google Scholar 

  7. Liu D, Bosley T M. (2003):Silicone nasolacrimal intubation with mitomycin C-a prospective, randomized, double-masked study.Ophthalmology 110(2):306–10.

    Article  PubMed  Google Scholar 

  8. Rahbar R, Jones D T, Nuss R C et al. (2002):The role of Mitomycin in the prevention and treatment of scar formation in the paediatric aerodigestive tract.Arch Otolaryngol Head Neck Surg. 128;401–406.

    PubMed  Google Scholar 

  9. Selig YK, Biesman BS, Rebeiz EE. (2000):Topical Application of Mitomycin C in endoscopic dacryocystorhinostomy.Am J Rhinol. 14(3):205–7.

    Article  PubMed  CAS  Google Scholar 

  10. Singh M, Jain V, Gupta SC, Singh SP.(2004):Intranasal Endoscopic DCR (End-DCR) In Cases Of Dacryocystitis.Ind. J. Otolaryngol. And Head Neck Surg. 56(3);177–83.

    Google Scholar 

  11. Zilelioglu G, Ugurbas SH, Anadolu Y, Akiner M, Akturk T. (1998):Adjunctive use of mitomycin C on endoscopic lacrimal surgery.Br. J. Ophthalmol. 82 (1);63–6.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of ENT and Head - Neck Surgery, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, Kolkata

    Soumitra Ghosh, Amitabha Roychoudhury & B. K. Roychaudhuri

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  1. Soumitra Ghosh
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  2. Amitabha Roychoudhury
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  3. B. K. Roychaudhuri
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Ghosh, S., Roychoudhury, A. & Roychaudhuri, B.K. Use of mitomycin C in endo-DCR. Indian J Otolaryngol Head Neck Surg 58, 368–369 (2006). https://doi.org/10.1007/BF03049597

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