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The influence of hook-worm infection on the heart muscle—an experimental investigation

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Proceedings / Indian Academy of Sciences

Summary

  1. 1.

    The influence of hook-worm infection on the heart muscle is investigated by perfusing isolated frog hearts with different concentrations of blood sera of patients suffering from Ankylostomiasis.

  2. 2.

    It is observed that in concentrations of 1 in 106 and 1 in 105 the sera produce a diminution of the Amplitude of the beats indicating the presence of a toxic factor in the sera.

  3. 3.

    The toxic effect disappears in a few cases after iron therapy and disappears completely or is considerably diminished after anthelmintic treatment.

  4. 4.

    It is concluded subject to further experimentation that some factor yet to be isolated is present in the blood serum in Ankylostomiasis which exercises a toxic effect on the cardiac muscle and on the blood-forming organs.

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References

  • Chandler, A. C.Hook-Worm Disease, 1929 Ed., Macmillan & Co.

  • Heilig, R., and Visveswar, S. K.Ind. Med.Gaz., 1942,77, 257.

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  • Langen De, C. D.Trans. 5th Bien. Congress, Far Eastern Assn. Trop. Med., Singapore, 1923.

  • Napier, L. E., Das Gupta, C. R., and Majumdar, D. N.Ind. Med. Gaz., 1941,76, 1.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University Medical College, Mysore

    G. S. Raghunatha Rao & N. Anandalwar

Authors
  1. G. S. Raghunatha Rao
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  2. N. Anandalwar
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Additional information

Communicated by Prof. A. Subba Rau,f.a.sc.

Our thanks are due to Dr. Robert Heilig for his co-operation in the investigation and for furnishing the cardiographic results. We thank Mr. S. K. Visveswar for supplying the blood samples, hœemoglobin values and other clinical data.

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Raghunatha Rao, G.S., Anandalwar, N. The influence of hook-worm infection on the heart muscle—an experimental investigation. Proc. Indian Acad. Sci. 19, 204–210 (1944). https://doi.org/10.1007/BF03049468

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  • DOI: https://doi.org/10.1007/BF03049468

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