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The mode of action of drugs on unstriated muscle and the nature of inhibition

  • Published:
Proceedings / Indian Academy of Sciences

An Erratum to this article was published on 01 January 1946

Summary

  1. (1)

    Both adrenaline and acetylcholine produce contraction of unstriated muscle in the electrolyte-free medium, suggesting that their action is due to mobilisation of ions within the fibres.

  2. (2)

    They also produce contractions or inhibitions resembling those produced by ions outside the fibres; this suggests that they may also act by sensitising the muscle to ions outside.

  3. (3)

    Acetylcholine produces two kinds of contractions in the unstriated muscle.

  4. (4)

    Inhibition is really an excitatory process, masked by adaptation.

  5. (5)

    Adrenaline inhibition is antagonised by potassium, ammonium, electric current, hydrogen ions, and increase in osmotic pressure; it is potentiated by calcium, hydrogen ions, and also by electric current. Adrenaline thus produces two kinds of inhibitions.

  6. (6)

    Eserine acts by means other than combining with choline-esterase.

  7. (7)

    Ephedrine potentiates adrenaline also by a process of summation.

  8. (8)

    Drugs produce a contraction, which is a class by itself.

  9. (9)

    The optimum temperature for adrenaline inhibition is 30°

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References

  • Dale, H. H.J. Physiol, 1913,46, 29.

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  • Gunn, J. A.Cushneys Pharmacology and Theraputics, 1941.

  • Narayana, B., and Singh, I.Proc. Ind. Acad. Sci., 1944,22, 192.

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Authors and Affiliations

  1. Department of Physiology, Dow Medical College, Hyderabad, Sind

    Inderjit Singh

Authors
  1. Inderjit Singh
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/BF03049512.

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Singh, I. The mode of action of drugs on unstriated muscle and the nature of inhibition. Proc. Indian Acad. Sci. 22, 123–132 (1945). https://doi.org/10.1007/BF03048771

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  • DOI: https://doi.org/10.1007/BF03048771

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