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A double blind clinical trial of Diosmin (Venex) a bioflavonoid in acute allergic rhinitis

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Abstract

A doubnle blind randomised clinical trial of Diosmin against placebo was conducted in 150 patients with acute allergic rhinitis. Patients who satisfied the inclusion criteria were included into the study. Diosmin and placebo were given 300 mg three times daily in respective groups. The treatment lasted for a week and follow up for another week. The Parameters studied included rhinorrhoea, sneezings and nasal obstruction. The nasal smear was also studied for eosinophil count. At the end of the clinical trial patients who received Diosmin were significantly improved in all the parameters and the eosino phil count has also reduced in the nasal smear in comparison to the patients who received placebo. Diosmin hastens the recovery from acute phase and offers therapeutic promise in acute allergic rhinitis compared to placebo. No Significant side effects were observed with the drug.

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References

  1. BEHAR, A., VALENSI, P., DE CHAMPVALLINA, M. et al (1989): Capillary filtration and lymphatic resorption in diabetes. International Angiology 8 (suppliment 4) 27–29.

    PubMed  CAS  Google Scholar 

  2. DAMON, M., FLANDRE, O., MICHEL, F. et al (1987): Effect of chronic treatment with purified flavonoid fraction on inflammatory granuloma in the rat. Arzneim-Forseh / drug Research 37 (II): 11149–53.

    Google Scholar 

  3. DAS GUPTA, G. AND GAMBHIR, S. S. (1988): Bioflavonoids and vasoactive mediator release from mast cells. Indian Journal of Physiology Pharmacology 32: 29–36.

    CAS  Google Scholar 

  4. KRAUSE, H.F., (1992): Pharmacology of upper respiratory allergy. The otolaryngologie clinics of North America 25: 135–150.

    CAS  Google Scholar 

  5. LABRID, C., DUHAULT, J. AND VIX, C. (1978): Proprietes pharmacologiques de daflon 500 mg. Journal of Internal Medicine. (suppliment 88) 7–13.

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Guntur Medical College, Guntur-552001 A.P.

    V. Phanindra Kumar & D. Govinda Das

Authors
  1. V. Phanindra Kumar
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  2. D. Govinda Das
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Kumar, V.P., Das, D.G. A double blind clinical trial of Diosmin (Venex) a bioflavonoid in acute allergic rhinitis. IJO & HNS 47, 51–53 (1995). https://doi.org/10.1007/BF03047921

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  • DOI: https://doi.org/10.1007/BF03047921

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