Conclusions
Thus it appears from our studies that serial section offers a good tool for assessing the biological nature of laryngeal cancer as well as radiation reaction. It gives an idea of spread of cancer in all three dimensions which helps immensely in planning the management. Non involvement of conus elasticus, intralaryngeal muscles, the submucous glands and cartilages suggests a good prognosis. Pre-epiglottic space was found to be invaded by tumour from anterior commissural region and supraglottis. By serial section one is able to have a good idea about the immune response that is playing a part. Stage of cell differentiation of the growth is not absolutely parallel to the invasiveness of the growth. In addition, radiation reactions can be assessed. Here we have found tumour regression by radiation therapy not to be centripetal as suggested by many.
We must emphasise that our findings are based on three case studies; therefore it will need more studies to substantiate our findings and conclusions.
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References
Alexander, F.W. (1963): Micropathology of radiation reaction in the larynx. Ann. Otol. Rhinol, laryngol. 72, 831–841.
Bocca, E. et al. (1968): Supraglottic surgery of the larynx Ann. Otol. Rhinol laryngol 77, 1005–1026.
Broyles, E. N. (1943): The anterior commissure tendon. Ann. Otol. Rhinal, laryngol 52, 342.
Bridger, G. P. et al (1972): Cancer spread in the larynx. Arch. Otolaryng. 95: 497–505.
Jan Oloffson et al (1972): Anterior Commissure Carcinoma. Arch. Otolaryng. 95: 230–239.
Kirschner, J.A. (1969): One hundred laryngeal cancer studied by serial section. Annals. Otol. Rhino. Laryngol 78, 689–709.
LeRoux Robert, J. (1936): Less epitheliomas intralarynges Thesis, Gaston Doin and Cie, Paris. (Quoted by Kirchner, J A. 1969).
Norris, C.M. et al (1970): A correlation of clinical staging, pathological findings and 5 year end results in surgically treated cancer of the larynx. Ann. Oto. Rhinol Laryngol. 79, 1033–1048.
Pressman, J. J. (1960): Anatomical studies related to the dissemination of cancer of the larynx. Trans. Amer. Acad. Ophthal. Otoloaryngol, 64, 628–638.
Tucker, G. (Jr) (1963): Some clinical inferences from the study of serial Laryngol section. Laryngoscope, 73:728–748.
Tucker, G. (Jr) (1961): A histological method for the study of the sprade of carcinoma within the larynx. Ann. Otol. Rhinol laryngol 70: 910–921.
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Deka, R.C., Roy, S., Kacker, S.K. et al. Evaluation of biological potential of laryngeal carcinoma by whole organ serial section a preliminary report. Ind. J. Otol. 26, 11–16 (1974). https://doi.org/10.1007/BF03047770
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DOI: https://doi.org/10.1007/BF03047770